Literature DB >> 17698628

Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.

Christophe Loup1, Joël Lelièvre, Françoise Benoit-Vical, Bernard Meunier.   

Abstract

Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of beta-hematin formation in 10 M acetate medium at pH 5.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17698628      PMCID： PMC2043280          DOI： 10.1128/AAC.00239-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully acknowledged for discussions on NMR data.

Authors:  Anne Robert; Jérôme Cazelles; Bernard Meunier
Journal:  Angew Chem Int Ed Engl       Date:  2001-05-18       Impact factor: 15.336

2.  Artemisinin antimalarials do not inhibit hemozoin formation.

Authors:  Richard K Haynes; Diego Monti; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Piero Olliaro
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

3.  A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds.

Authors:  E Deharo; R N García; P Oporto; A Gimenez; M Sauvain; V Jullian; H Ginsburg
Journal:  Exp Parasitol       Date:  2002-04       Impact factor: 2.011

4.  The antimalarial drug artemisinin alkylates heme in infected mice.

Authors:  Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-09       Impact factor: 11.205

5.  A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro.

Authors:  A Dorn; S R Vippagunta; H Matile; A Bubendorf; J L Vennerstrom; R G Ridley
Journal:  Biochem Pharmacol       Date:  1998-03-15       Impact factor: 5.858

6.  Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.

Authors:  Françoise Benoit-Vical; Joël Lelièvre; Antoine Berry; Caroline Deymier; Odile Dechy-Cabaret; Jérôme Cazelles; Christophe Loup; Anne Robert; Jean-François Magnaval; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

7.  Involvement of lipids in ferriprotoporphyrin IX polymerization in malaria.

Authors:  C D Fitch; G Z Cai; Y F Chen; J D Shoemaker
Journal:  Biochim Biophys Acta       Date:  1999-05-31

8.  Heme alkylation by artesunic acid and trioxaquine DU1301, two antimalarial trioxanes.

Authors:  Sophie A-L Laurent; Christophe Loup; Sophie Mourgues; Anne Robert; Bernard Meunier
Journal:  Chembiochem       Date:  2005-04       Impact factor: 3.164

9.  Standardization of the physicochemical parameters to assess in vitro the beta-hematin inhibitory activity of antimalarial drugs.

Authors:  S Parapini; N Basilico; E Pasini; T J Egan; P Olliaro; D Taramelli; D Monti
Journal:  Exp Parasitol       Date:  2000-12       Impact factor: 2.011

10.  Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay.

Authors:  Abhai K Tripathi; Shabana I Khan; Larry A Walker; Babu L Tekwani
Journal:  Anal Biochem       Date:  2004-02-01       Impact factor: 3.365
View more
  15 in total

1.  Selection of a trioxaquine as an antimalarial drug candidate.

Authors:  Frédéric Coslédan; Laurent Fraisse; Alain Pellet; François Guillou; Benjamin Mordmüller; Peter G Kremsner; Alicia Moreno; Dominique Mazier; Jean-Pierre Maffrand; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-05       Impact factor: 11.205

2.  Insights into the role of heme in the mechanism of action of antimalarials.

Authors:  Jill M Combrinck; Tebogo E Mabotha; Kanyile K Ncokazi; Melvin A Ambele; Dale Taylor; Peter J Smith; Heinrich C Hoppe; Timothy J Egan
Journal:  ACS Chem Biol       Date:  2012-10-11       Impact factor: 5.100

3.  Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug.

Authors:  Anne Robert; Catherine Claparols; Benoit Witkowski; Françoise Benoit-Vical
Journal:  Antimicrob Agents Chemother       Date:  2013-06-10       Impact factor: 5.191

Review 4.  Discovery, mechanisms of action and combination therapy of artemisinin.

Authors:  Liwang Cui; Xin-zhuan Su
Journal:  Expert Rev Anti Infect Ther       Date:  2009-10       Impact factor: 5.091

5.  The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

Authors:  Fatima Bousejra-El Garah; Catherine Claparols; Françoise Benoit-Vical; Bernard Meunier; Anne Robert
Journal:  Antimicrob Agents Chemother       Date:  2008-06-16       Impact factor: 5.191

6.  Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

Authors:  Carmony L Hartwig; Andrew S Rosenthal; John D'Angelo; Carol E Griffin; Gary H Posner; Roland A Cooper
Journal:  Biochem Pharmacol       Date:  2008-10-19       Impact factor: 5.858

7.  Design, synthesis and bioactivities of phenithionate analogues or derivatives for anti-schistosomiasis.

Authors:  Shiyang Zhou; Gangliang Huang
Journal:  Medchemcomm       Date:  2017-12-22       Impact factor: 3.597

8.  Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.

Authors:  Francis W Muregi; Akira Ishih
Journal:  Drug Dev Res       Date:  2010-02       Impact factor: 4.360

9.  Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

Authors:  Julien Portela; Jérôme Boissier; Benjamin Gourbal; Vincent Pradines; Vincent Collière; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal:  PLoS Negl Trop Dis       Date:  2012-02-14

10.  Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.

Authors:  Benoit Witkowski; Joel Lelièvre; Marie-Laure Nicolau-Travers; Xavier Iriart; Patrice Njomnang Soh; Fatima Bousejra-Elgarah; Bernard Meunier; Antoine Berry; Françoise Benoit-Vical
Journal:  PLoS One       Date:  2012-03-05       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.