Literature DB >> 1128545

The effect of methylxanthines on chromosomes of human lyphocytes in culture.

D Weinstein, I Mauer, M L Katz, S Kazmer.   

Abstract

The effect of caffeine (I,3,7-trimethylxanthine), theophylline (I,3-dimethylxanthine), theobromine (3,7-dimethylxanthine), paraxanthine (I,7-dimethylxanthine) I-methylxanthine, 3-methylxanthine, and 7-methylxanthine added at the 48th h on the chromosomes of human lymphocytes in 72-h cultures has been investigated. Caffeine and the dimethylxanthines cause breakage at 750 mug/ml, with caffeine the most, and paraxanthine the least clastogenic. I-Methylxanthine and dimethylxanthines with a methyl group in the I-position are the most effective in depressing mitotic indices. No chromosome damage was exhibited by the monomethylxanthines.

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Year:  1975        PMID： 1128545     DOI： 10.1016/0165-1161(75)90064-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  4 in total

Review 1.  Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact.

Authors:  Federico M Goodsaid; Shashi Amur; Jiri Aubrecht; Michael E Burczynski; Kevin Carl; Jennifer Catalano; Rosane Charlab; Sandra Close; Catherine Cornu-Artis; Laurent Essioux; Albert J Fornace; Lois Hinman; Huixiao Hong; Ian Hunt; David Jacobson-Kram; Ansar Jawaid; David Laurie; Lawrence Lesko; Heng-Hong Li; Klaus Lindpaintner; James Mayne; Peter Morrow; Marisa Papaluca-Amati; Timothy W Robison; John Roth; Ina Schuppe-Koistinen; Leming Shi; Olivia Spleiss; Weida Tong; Sharada L Truter; Jacky Vonderscher; Agnes Westelinck; Li Zhang; Issam Zineh
Journal:  Nat Rev Drug Discov       Date:  2010-06       Impact factor: 84.694

2.  Sister chromatid exchanges induced by methylxanthines contained in coffee, tea and cocoa.

Authors:  H W Renner
Journal:  Experientia       Date:  1982-05-15

3.  Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.

Authors:  Heng-Hong Li; Daniel R Hyduke; Renxiang Chen; Pamela Heard; Carole L Yauk; Jiri Aubrecht; Albert J Fornace
Journal:  Environ Mol Mutagen       Date:  2015-03-02       Impact factor: 3.216

4.  Study of the biological effects of theophylline on V79 cells: viability, membrane permeability, and metabolic cooperation.

Authors:  A Gabelova; D Slamenova; T Bohusova
Journal:  Cell Biol Toxicol       Date:  1991-04       Impact factor: 6.691
  4 in total

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