| Literature DB >> 11277524 |
A Guzman-Perez1, R T Wester, M C Allen, J A Brown, A R Buchholz, E R Cook, W W Day, E S Hamanaka, S P Kennedy, D R Knight, P J Kowalczyk, R B Marala, C J Mularski, W A Novomisle, R B Ruggeri, W R Tracey, R J Hill.
Abstract
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the molecule adopts due to the presence of a cyclopropyl and a 5-quinolinyl substituent on the central pyrazole ring of the molecule.Entities:
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Year: 2001 PMID： 11277524 DOI： 10.1016/s0960-894x(01)00059-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823