Literature DB >> 421853

Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.

T A Barbolt, R Abraham.   

Abstract

Rats were given 6600 ppm of butylated hydroxytoluene (BHT) in the diet along with 10 weekly oral doses of dimethylhydrazine (DMH, 30 MG/KG). The incidence and mean number of colonic tumors produced were similar to that of rats given DMH alone. Thus, BHT did not provide any protective effect against colon carcinogenesis.

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Year:  1979        PMID： 421853     DOI： 10.1007/bf01920650

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane.

Authors:  E K Weisburger; R P Evarts
Journal:  Food Cosmet Toxicol       Date:  1977-04

2.  Lysosomal enzymes in macrophages of colonic tumors induced in rats by 1,2-dimethylhydrazine dihydrochloride.

Authors:  R Abraham; T A Barbolt
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

3.  Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats.

Authors:  J M Ward
Journal:  Lab Invest       Date:  1974-04       Impact factor: 5.662

4.  Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats.

Authors:  B M Ulland; J H Weisburger; R S Yamamoto; E K Weisburger
Journal:  Food Cosmet Toxicol       Date:  1973-04

5.  The effect of substituted phenols on liver weights and liver enzymes in the rat: structure-activity relationships.

Authors:  D Gilbert; A D Martin; S D Gangolli; R Abraham; L Goldberg
Journal:  Food Cosmet Toxicol       Date:  1969-11

6.  Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.

Authors:  L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1972-05       Impact factor: 13.506

7.  The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat.

Authors:  T A Barbolt; R Abraham
Journal:  Proc Soc Exp Biol Med       Date:  1978-04

8.  Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine.

Authors:  E Fiala
Journal:  Cancer       Date:  1975-12       Impact factor: 6.860

9.  Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.

Authors:  L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1975-04       Impact factor: 13.506

10.  Effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide.

Authors:  P H Grantham; J H Weisburger; E K Weisburger
Journal:  Food Cosmet Toxicol       Date:  1973-04
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