Literature DB >> 23519483

Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase.

Mikołaj Chromiński1, Keith Ó Proinsias, Emil Martin, Dorota Gryko.   

Abstract

A new cobyrinate/protoporphyrin IX molecular hybrids were prepared via CuAAC reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties followed by the CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase showing strong linker length/activation dependence.

Entities:  

Keywords:  Protoporphyrin IX; Vitamin B12; enzyme activation; ‘click’ chemistry

Year:  2013        PMID： 23519483      PMCID： PMC3600653          DOI： 10.1002/ejoc.201201303

Source DB:  PubMed          Journal:  European J Org Chem        ISSN： 1099-0690


  35 in total

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5.  Quick and highly efficient copper-catalyzed cycloaddition of organic azides with terminal alkynes.

Authors:  Dong Wang; Mingming Zhao; Xiang Liu; Yongxin Chen; Na Li; Baohua Chen
Journal:  Org Biomol Chem       Date:  2011-10-24       Impact factor: 3.876

6.  Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.

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Review 7.  Cu-free click cycloaddition reactions in chemical biology.

Authors:  John C Jewett; Carolyn R Bertozzi
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8.  Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin.

Authors:  G J Russell-Jones; S W Westwood; A D Habberfield
Journal:  Bioconjug Chem       Date:  1995 Jul-Aug       Impact factor: 4.774

Review 9.  Hybrid molecules with a dual mode of action: dream or reality?

Authors:  Bernard Meunier
Journal:  Acc Chem Res       Date:  2007-08-01       Impact factor: 22.384

10.  Efficient functionalization of carbon nanotubes with porphyrin dendrons via click chemistry.

Authors:  Thomas Palacin; Hung Le Khanh; Bruno Jousselme; Pascale Jegou; Arianna Filoramo; Christian Ehli; Dirk M Guldi; Stéphane Campidelli
Journal:  J Am Chem Soc       Date:  2009-10-28       Impact factor: 15.419
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Review 1.  The Red Color of Life Transformed - Synthetic Advances and Emerging Applications of Protoporphyrin IX in Chemical Biology.

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Journal:  European J Org Chem       Date:  2020-03-30

Review 2.  Functionalised Cofactor Mimics for Interactome Discovery and Beyond.

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Journal:  Angew Chem Int Ed Engl       Date:  2022-05-31       Impact factor: 16.823
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