Literature DB >> 11249126

Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones.

S Mukherjee1, V Kumar, A K Prasad, H G Raj, M E Bracke, C E Olsen, S C Jain, V S Parmar.   

Abstract

Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant.

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Year:  2001        PMID： 11249126     DOI： 10.1016/s0968-0896(00)00249-2

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

1.  Crystal structure of (E)-1-(1-hy-droxy-naphthalen-2-yl)-3-(2,3,4-tri-meth-oxy-phen-yl)prop-2-en-1-one.

Authors:  J Srividya; D Reuben Jonathan; B K Revathi; G Anbalagan
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-29

2.  New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.

Authors:  M Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu
Journal:  Bioorg Med Chem       Date:  2011-03-04       Impact factor: 3.641

3.  Dietary chalcones with chemopreventive and chemotherapeutic potential.

Authors:  Barbora Orlikova; Deniz Tasdemir; Frantisek Golais; Mario Dicato; Marc Diederich
Journal:  Genes Nutr       Date:  2011-02-04       Impact factor: 5.523

4.  (2E)-1-(3-Chloro-phen-yl)-3-(4-chloro-phen-yl)prop-2-en-1-one.

Authors:  Jerry P Jasinski; Ray J Butcher; B Narayana; K Veena; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-03

5.  (E)-3-(4-Fluoro-phen-yl)-1-[4-(methyl-sulfan-yl)phen-yl]prop-2-en-1-one.

Authors:  N Anuradha; A Thiruvalluvar; M Mahalinga; R J Butcher
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-15

Review 6.  Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review.

Authors:  Mamdouh F A Mohamed; Gamal El-Din A Abuo-Rahma
Journal:  RSC Adv       Date:  2020-08-21       Impact factor: 4.036

7.  Crystal structure of (E)-3-(3,4-di-meth-oxy-phen-yl)-1-(1-hy-droxy-naphthalen-2-yl)prop-2-en-1-one.

Authors:  K S Ezhilarasi; D Reuben Jonathan; R Vasanthi; B K Revathi; G Usha
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-04-30

8.  Crystal structure and Hirshfeld surface analysis of (E)-3-(2-chloro-6-fluoro-phen-yl)-1-(3-fluoro-4-meth-oxy-phen-yl)prop-2-en-1-one.

Authors:  Nur Hafiq Hanif Hassan; Amzar Ahlami Abdullah; Suhana Arshad; Nuridayanti Che Khalib; Ibrahim Abdul Razak
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-04-22

9.  Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors.

Authors:  Sayed K Ramadan; Eman Z Elrazaz; Khaled A M Abouzid; Abeer M El-Naggar
Journal:  RSC Adv       Date:  2020-08-10       Impact factor: 4.036

Review 10.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388
  10 in total

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