OBJECTIVE: Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence. METHOD: Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25 cocaine-dependent and 20 healthy subjects. RESULTS: Normalized caudate and putamen volumes were 3.40% and 9.18% larger, respectively, in the cocaine-dependent subjects. CONCLUSIONS: These observations suggest that deficits in dopaminergic function associated with cocaine dependence may contribute to striatal hypertrophy.
OBJECTIVE: Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence. METHOD: Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25 cocaine-dependent and 20 healthy subjects. RESULTS: Normalized caudate and putamen volumes were 3.40% and 9.18% larger, respectively, in the cocaine-dependent subjects. CONCLUSIONS: These observations suggest that deficits in dopaminergic function associated with cocaine dependence may contribute to striatal hypertrophy.
Authors: Simone Kühn; Florian Schmiedek; Hannes Noack; Elisabeth Wenger; Nils C Bodammer; Ulman Lindenberger; Martin Lövden Journal: Hum Brain Mapp Date: 2012-02-14 Impact factor: 5.038
Authors: Jody Tanabe; Jason R Tregellas; Manish Dalwani; Laetitia Thompson; Elizabeth Owens; Thomas Crowley; Marie Banich Journal: Biol Psychiatry Date: 2008-09-18 Impact factor: 13.382
Authors: Anderson Mon; Timothy C Durazzo; Christoph Abe; Stefan Gazdzinski; David Pennington; Thomas Schmidt; Dieter J Meyerhoff Journal: Drug Alcohol Depend Date: 2014-09-19 Impact factor: 4.492
Authors: Jaime S Ide; Sheng Zhang; Sien Hu; Rajita Sinha; Carolyn M Mazure; Chiang-Shan R Li Journal: Drug Alcohol Depend Date: 2013-09-17 Impact factor: 4.492
Authors: Daniel Mamah; Michael P Harms; Lei Wang; Deanna Barch; Paul Thompson; Jaeyun Kim; Michael I Miller; John G Csernansky Journal: Biol Psychiatry Date: 2008-03-04 Impact factor: 13.382