Literature DB >> 11206438

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

S L Colletti1, R W Myers, S J Darkin-Rattray, A M Gurnett, P M Dulski, S Galuska, J J Allocco, M B Ayer, C Li, J Lim, T M Crumley, C Cannova, D M Schmatz, M J Wyvratt, M H Fisher, P T Meinke.   

Abstract

Apicidin, a natural product recently isolated at Merck, inhibits both mammalian and protozoan histone deacetylases (HDACs). The conversion of apicidin, a nanomolar inhibitor of HDACs, into a series of side-chain analogues that display picomolar enzyme affinity is described within this structure-activity study.

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Year:  2001        PMID： 11206438     DOI： 10.1016/s0960-894x(00)00604-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.

Authors:  William Guerrant; Sandra C Mwakwari; Po C Chen; Shabana I Khan; Babu L Tekwani; Adegboyega K Oyelere
Journal:  ChemMedChem       Date:  2010-08-02       Impact factor: 3.466

Review 2.  Macrocyclic histone deacetylase inhibitors.

Authors:  Sandra C Mwakwari; Vishal Patil; William Guerrant; Adegboyega K Oyelere
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

Review 3.  Discovery and mechanism of natural products as modulators of histone acetylation.

Authors:  Lilibeth A Salvador; Hendrik Luesch
Journal:  Curr Drug Targets       Date:  2012-07       Impact factor: 3.465

4.  Potential non-oncological applications of histone deacetylase inhibitors.

Authors:  Katherine Ververis; Tom C Karagiannis
Journal:  Am J Transl Res       Date:  2011-10-10       Impact factor: 4.060

5.  Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.

Authors:  Renata C Ferreira; Evgenya Y Popova; Jessica James; Marcelo R S Briones; Samuel S Zhang; Colin J Barnstable
Journal:  J Biol Chem       Date:  2016-12-27       Impact factor: 5.157

6.  Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.

Authors:  Crescent R Isham; Jennifer D Tibodeau; Wendy Jin; Ruifang Xu; Michael M Timm; Keith C Bible
Journal:  Blood       Date:  2006-11-07       Impact factor: 22.113

7.  Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.

Authors:  Christian A Olsen; M Reza Ghadiri
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446

8.  Potent antimalarial activity of histone deacetylase inhibitor analogues.

Authors:  K T Andrews; T N Tran; A J Lucke; P Kahnberg; G T Le; G M Boyle; D L Gardiner; T S Skinner-Adams; D P Fairlie
Journal:  Antimicrob Agents Chemother       Date:  2008-01-22       Impact factor: 5.191

9.  Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens.

Authors:  M A Pfaller; S A Messer; N Georgopapadakou; L A Martell; J M Besterman; D J Diekema
Journal:  J Clin Microbiol       Date:  2009-09-30       Impact factor: 5.948

Review 10.  Toxoplasma histone acetylation remodelers as novel drug targets.

Authors:  Laura Vanagas; Victoria Jeffers; Silvina S Bogado; Maria C Dalmasso; William J Sullivan; Sergio O Angel
Journal:  Expert Rev Anti Infect Ther       Date:  2012-10       Impact factor: 5.091
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