Literature DB >> 11179887

The Lac repressor: a second generation of structural and functional studies.

C E Bell1, M Lewis.   

Abstract

In the past year, the crystal structure of a dimeric version of the Escherichia coli Lac repressor bound to operator DNA was determined at 2.6A resolution, providing a closer view of the operator-bound conformation of the repressor. Refined NMR studies of the DNA-binding portion of the repressor complexed to operator DNA have revealed further details of the unique DNA-binding interactions of the repressor. The structural studies have been complemented by continued biochemical studies, with the overall goal of understanding the mechanism of allosteric regulation.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11179887     DOI： 10.1016/s0959-440x(00)00180-9

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  21 in total

1.  Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR.

Authors:  Liskin Swint-Kruse; Christopher Larson; B Montgomery Pettitt; Kathleen Shive Matthews
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

2.  Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.

Authors:  Charalampos G Kalodimos; Alexandre M J J Bonvin; Roberto K Salinas; Rainer Wechselberger; Rolf Boelens; Robert Kaptein
Journal:  EMBO J       Date:  2002-06-17       Impact factor: 11.598

3.  Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential.

Authors:  Michael Slutsky; Leonid A Mirny
Journal:  Biophys J       Date:  2004-10-01       Impact factor: 4.033

4.  Extrinsic interactions dominate helical propensity in coupled binding and folding of the lactose repressor protein hinge helix.

Authors:  Hongli Zhan; Liskin Swint-Kruse; Kathleen Shive Matthews
Journal:  Biochemistry       Date:  2006-05-09       Impact factor: 3.162

5.  Functional domains of the Bacillus subtilis transcription factor AraR and identification of amino acids important for nucleoprotein complex assembly and effector binding.

Authors:  Irina Saraiva Franco; Luís Jaime Mota; Cláudio Manuel Soares; Isabel de Sá-Nogueira
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

6.  Structural analysis of lac repressor bound to allosteric effectors.

Authors:  Robert Daber; Steven Stayrook; Allison Rosenberg; Mitchell Lewis
Journal:  J Mol Biol       Date:  2007-04-19       Impact factor: 5.469

7.  Refining the binding of the Escherichia coli flagellar master regulator, FlhD4C2, on a base-specific level.

Authors:  Yi-Ying Lee; Clive S Barker; Philip Matsumura; Robert Belas
Journal:  J Bacteriol       Date:  2011-06-17       Impact factor: 3.490

Review 8.  Biomolecular Assemblies: Moving from Observation to Predictive Design.

Authors:  Corey J Wilson; Andreas S Bommarius; Julie A Champion; Yury O Chernoff; David G Lynn; Anant K Paravastu; Chen Liang; Ming-Chien Hsieh; Jennifer M Heemstra
Journal:  Chem Rev       Date:  2018-10-03       Impact factor: 60.622

9.  Opine-based Agrobacterium competitiveness: dual expression control of the agrocinopine catabolism (acc) operon by agrocinopines and phosphate levels.

Authors:  H Stanley Kim; Hyojeong Yi; Jaehee Myung; Kevin R Piper; Stephen K Farrand
Journal:  J Bacteriol       Date:  2008-03-14       Impact factor: 3.490

10.  Structure-based predictive models for allosteric hot spots.

Authors:  Omar N A Demerdash; Michael D Daily; Julie C Mitchell
Journal:  PLoS Comput Biol       Date:  2009-10-09       Impact factor: 4.475
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.