| Literature DB >> 11170665 |
Y J Lim1, H S Park, K S Im, C Lee, J Hong, M Lee, D Kim Dk, J H Jung.
Abstract
Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication.Entities:
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Year: 2001 PMID： 11170665 DOI： 10.1021/np000252d
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050