Glucose tolerance predicts performance on tests of memory and cognition.

The hypothesis that the ability to control blood glucose levels influence memory and other aspects of cognition was considered. Individual differences in the ability to control blood glucose were measured by giving a glucose tolerance test (GTT) to 46 young adult females. A factor analysis of a series of measures of glucose tolerance produced four dimensions. A week later, having eaten their normal breakfast, they took tests of memory, reaction times and vigilance. The speed with which blood glucose increased, having its lowest point in the GTT, was associated with memory measured a week later. While performing the tests those with higher levels of blood glucose on arrival in the laboratory had quicker reaction times when monitoring eight but not four, two or one lamps. The finding was interpreted as demonstrating that higher levels of blood glucose specially influence tasks placing higher demands on the brain.