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Literature DB >> 11119548

Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates.

Abstract

Twelve Pseudomonas aeruginosa cystic fibrosis isolates that are not able to exert a type III secretion system (TTSS)-dependent cytotoxicity towards phagocytes have been further studied. The strains, although possessing TTSS genes and exsA, which encodes a positive regulator of the TTSS regulon, showed no transcriptional activation of the exsCBA regulatory operon. The expression of exsA in trans restored the in vitro secretion of TTSS proteins and ex vivo cytotoxicity.

Entities: Disease

Mesh：

Substances：

Year: 2001 PMID： 11119548 PMCID： PMC97914 DOI： 10.1128/IAI.69.1.538-542.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

28 in total

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Journal: Infect Immun Date: 1999-11 Impact factor: 3.441

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Journal: J Clin Invest Date: 1992-10 Impact factor: 14.808

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Authors: J S Elborn; D J Shale
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Authors: T L Yahr; D W Frank
Journal: J Bacteriol Date: 1994-07 Impact factor: 3.490

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Journal: Gene Date: 1994-10-11 Impact factor: 3.688

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Authors: D W Martin; M J Schurr; M H Mudd; J R Govan; B W Holloway; V Deretic
Journal: Proc Natl Acad Sci U S A Date: 1993-09-15 Impact factor: 11.205

40 in total

1. Activation of the Pseudomonas aeruginosa type III secretion system requires an intact pyruvate dehydrogenase aceAB operon.

Authors: Denis Dacheux; Olivier Epaulard; Arjan de Groot; Benoit Guery; Rozen Leberre; Ina Attree; Benoit Polack; Bertrand Toussaint
Journal: Infect Immun Date: 2002-07 Impact factor: 3.441

2. V-antigen genotype and phenotype analyses of clinical isolates of Pseudomonas aeruginosa.

Authors: Leonard R Allmond; Temitayo Ajayi; Kiyoshi Moriyama; Jeanine P Wiener-Kronish; Teiji Sawa
Journal: J Clin Microbiol Date: 2004-08 Impact factor: 5.948

3. Full virulence of Pseudomonas aeruginosa requires OprF.

Authors: Laurène Fito-Boncompte; Annelise Chapalain; Emeline Bouffartigues; Hichem Chaker; Olivier Lesouhaitier; Gwendoline Gicquel; Alexis Bazire; Amar Madi; Nathalie Connil; Wilfried Véron; Laure Taupin; Bertrand Toussaint; Pierre Cornelis; Qing Wei; Koki Shioya; Eric Déziel; Marc G J Feuilloley; Nicole Orange; Alain Dufour; Sylvie Chevalier
Journal: Infect Immun Date: 2010-12-28 Impact factor: 3.441

Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates.

1. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa.

Review 2. Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells?

3. Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system.

4. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.

5. Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.

6. Pseudomonas aeruginosa contains an IHF-like protein that binds to the algD promoter.

Review 7. Cystic fibrosis. 2. Lung injury in cystic fibrosis.

8. Transcriptional organization of the trans-regulatory locus which controls exoenzyme S synthesis in Pseudomonas aeruginosa.

9. Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa.

10. Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.

1. Activation of the Pseudomonas aeruginosa type III secretion system requires an intact pyruvate dehydrogenase aceAB operon.

2. V-antigen genotype and phenotype analyses of clinical isolates of Pseudomonas aeruginosa.

3. Full virulence of Pseudomonas aeruginosa requires OprF.

4. Antibiotics as intermicrobial signaling agents instead of weapons.

5. Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections.

6. Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU.

7. The type III toxins of Pseudomonas aeruginosa disrupt epithelial barrier function.

8. Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA.

9. Anti-activator ExsD forms a 1:1 complex with ExsA to inhibit transcription of type III secretion operons.

10. PtrA is a periplasmic protein involved in Cu tolerance in Pseudomonas aeruginosa.