Literature DB >> 12065547

Activation of the Pseudomonas aeruginosa type III secretion system requires an intact pyruvate dehydrogenase aceAB operon.

Denis Dacheux1, Olivier Epaulard, Arjan de Groot, Benoit Guery, Rozen Leberre, Ina Attree, Benoit Polack, Bertrand Toussaint.   

Abstract

Pseudomonas aeruginosa clinical cystic fibrosis isolate CHA was mutagenized with Tn5Tc to identify new genes involved in type III secretion system (TTSS)-dependent cytotoxicity toward human polymorphonuclear neutrophils. Among 25 mutants affected in TTSS function, 14 contained the insertion at different positions in the aceAB operon encoding the PDH-E1 and -E2 subunits of pyruvate dehydrogenase. In PDH mutants, no transcriptional activation of TTSS genes in response to calcium depletion occurred. Expression in trans of ExsA restored TTSS function and cytotoxicity.

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Year:  2002        PMID： 12065547      PMCID： PMC128050          DOI： 10.1128/IAI.70.7.3973-3977.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates.

Authors:  D Dacheux; I Attree; B Toussaint
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

2.  Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors:  H J VOGEL; D M BONNER
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

Review 3.  Pathogenicity of microbes associated with cystic fibrosis.

Authors:  M L Hutchison; J R Govan
Journal:  Microbes Infect       Date:  1999-10       Impact factor: 2.700

4.  Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system.

Authors:  D Dacheux; I Attree; C Schneider; B Toussaint
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

5.  Pore-forming activity of type III system-secreted proteins leads to oncosis of Pseudomonas aeruginosa-infected macrophages.

Authors:  D Dacheux; J Goure; J Chabert; Y Usson; I Attree
Journal:  Mol Microbiol       Date:  2001-04       Impact factor: 3.501

6.  Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Authors:  C K Stover; X Q Pham; A L Erwin; S D Mizoguchi; P Warrener; M J Hickey; F S Brinkman; W O Hufnagle; D J Kowalik; M Lagrou; R L Garber; L Goltry; E Tolentino; S Westbrock-Wadman; Y Yuan; L L Brody; S N Coulter; K R Folger; A Kas; K Larbig; R Lim; K Smith; D Spencer; G K Wong; Z Wu; I T Paulsen; J Reizer; M H Saier; R E Hancock; S Lory; M V Olson
Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

Review 7.  Periplasmic protein thiol:disulfide oxidoreductases of Escherichia coli.

Authors:  R A Fabianek; H Hennecke; L Thöny-Meyer
Journal:  FEMS Microbiol Rev       Date:  2000-07       Impact factor: 16.408

8.  Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa.

Authors:  M H Rashid; A Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

9.  Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils.

Authors:  D Dacheux; B Toussaint; M Richard; G Brochier; J Croize; I Attree
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

10.  Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.

Authors:  D H Figurski; D R Helinski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205
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  45 in total

1.  V-antigen genotype and phenotype analyses of clinical isolates of Pseudomonas aeruginosa.

Authors:  Leonard R Allmond; Temitayo Ajayi; Kiyoshi Moriyama; Jeanine P Wiener-Kronish; Teiji Sawa
Journal:  J Clin Microbiol       Date:  2004-08       Impact factor: 5.948

2.  MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.

Authors:  Yongxin Jin; Hongjiang Yang; Mingqiang Qiao; Shouguang Jin
Journal:  J Bacteriol       Date:  2010-11-12       Impact factor: 3.490

Review 3.  Lipoic acid metabolism in microbial pathogens.

Authors:  Maroya D Spalding; Sean T Prigge
Journal:  Microbiol Mol Biol Rev       Date:  2010-06       Impact factor: 11.056

4.  Genetic characterization of Pseudomonas fluorescens SBW25 rsp gene expression in the phytosphere and in vitro.

Authors:  Robert W Jackson; Gail M Preston; Paul B Rainey
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

5.  Optimization of a type III secretion system-based Pseudomonas aeruginosa live vector for antigen delivery.

Authors:  Olivier Epaulard; Madiha Derouazi; Carole Margerit; Raphaël Marlu; Didier Filopon; Benoît Polack; Bertrand Toussaint
Journal:  Clin Vaccine Immunol       Date:  2007-12-19

Review 6.  DSB proteins and bacterial pathogenicity.

Authors:  Begoña Heras; Stephen R Shouldice; Makrina Totsika; Martin J Scanlon; Mark A Schembri; Jennifer L Martin
Journal:  Nat Rev Microbiol       Date:  2009-02-09       Impact factor: 60.633

7.  Cross-talk between type three secretion system and metabolism in Yersinia.

Authors:  Annika Schmid; Wibke Neumayer; Konrad Trülzsch; Lars Israel; Axel Imhof; Manfred Roessle; Guido Sauer; Susanna Richter; Susan Lauw; Eva Eylert; Wolfgang Eisenreich; Jürgen Heesemann; Gottfried Wilharm
Journal:  J Biol Chem       Date:  2009-02-25       Impact factor: 5.157

8.  Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa.

Authors:  Isar Dejban Golpasha; Seyed Fazlollah Mousavi; Parviz Owlia; Seyed Davar Siadat; Shiva Irani
Journal:  Bosn J Basic Med Sci       Date:  2015-05-25       Impact factor: 3.363

9.  Negative control of quorum sensing by RpoN (sigma54) in Pseudomonas aeruginosa PAO1.

Authors:  Karin Heurlier; Valerie Dénervaud; Gabriella Pessi; Cornelia Reimmann; Dieter Haas
Journal:  J Bacteriol       Date:  2003-04       Impact factor: 3.490

10.  PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage.

Authors:  Weihui Wu; Shouguang Jin
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490
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