| Literature DB >> 11114168 |
L Zakin1, B Reversade, B Virlon, C Rusniok, P Glaser, J M Elalouf, P Brulet.
Abstract
The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11114168 PMCID： PMC18928 DOI： 10.1073/pnas.011513398
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205