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Literature DB >> 11112090

In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats.

N N Gülerman¹, E E Oruç, F Kartal, S Rollas.

Abstract

It is known that substituted hydrazide hydrazone derivatives have several biological and pharmacological activities; there is limited literature on the metabolism of hydrazide hydrazones in rats. In our previous study, 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene]hydrazide (S) was found active against Staphylococcus aureus ATCC 29213. Therefore, we planned to study the in vivo metabolism of S in rats. The substrate was administered in doses of 50 mg/kg or 100 mg/kg intraperitoneally. Blood samples were collected at 0, 5, 15, 30, 45 min and 1, 1.5, 2, 4, 8, 12, 24, 48 h after administration. The substrate and its potential metabolites were separated using HPLC on a reverse phase system. 4-Fluorobenzoic acid and one unidentified metabolite were detected together with substrate.

Entities: Chemical

Mesh：

Substances：

Year: 2000 PMID： 11112090 DOI： 10.1007/BF03190075

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.569

10 in total

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7. Evaluation of some arylhydrazones of p-aminobenzoic acid hydrazide as antimicrobial agents and their in vitro hepatic microsomal metabolism.

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Journal: Boll Chim Farm Date: 1995 Jul-Aug

8. Anti-inflammatory activity of quinazolinoformazans.

Authors: R Kalsi; K Pande; T N Bhalla; J P Barthwal; G P Gupta; S S Parmar
Journal: J Pharm Sci Date: 1990-04 Impact factor: 3.534

9. Determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine in biological fluids by high-performance liquid chromatography.

Authors: W von Sassen; M Castro-Parra; E Musch; M Eichelbaum
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10. Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents.

Authors: H M Eisa; A S Tantawy; M M el-Kerdawy
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10 in total

9 in total

1. In vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats.

Authors: Bedia Koçyiğit Kaymakçioğlu; Yasemin Aktan; Sibel Süzen; Nesrin Gökhan; Semra Koyunoğlu; Kevser Erol; Akgül Yeşilada; Sevim Rollas
Journal: Eur J Drug Metab Pharmacokinet Date: 2005 Oct-Dec Impact factor: 2.441

9. Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates.

Authors: Ulviye Acar Cevik; Begum Nurpelin Saglik; Yusuf Ozkay; Zerrin Canturk; Juan Bueno; Fatih Demirci; Ali Savas Koparal
Journal: Curr Pharm Des Date: 2017 Impact factor: 3.116

9 in total

In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats.

1. Synthesis of substituted benzylidinohydrazines and their monoamine oxidase inhibitory and anticonvulsant properties.

2. Isonicotinyl hydrazones as antitubercular agents and derivatives for identification of aldehydes and ketones.

3. The in vivo metabolism of 5-(4-nitrophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats.

4. High-performance liquid-chromatographic assay for nitrofurantoin in plasma and urine.

5. Oxidative metabolites of 5-nitrofurans.

6. Synthesis and antifungal activity of some 2-aryl-3-substituted 4-thiazolidinones.

7. Evaluation of some arylhydrazones of p-aminobenzoic acid hydrazide as antimicrobial agents and their in vitro hepatic microsomal metabolism.

8. Anti-inflammatory activity of quinazolinoformazans.

9. Determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine in biological fluids by high-performance liquid chromatography.

10. Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents.

1. In vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats.

2. The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats.

3. HPLC analysis of in vivo metabolites of 4-nitrobenzoic acid [(5-nitro-2-thiopheneyl)methylene]hydrazide in rats.

4. The in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats.

5. Absorption of ethyl 2-cyanoacrylate tissue adhesive.

Review 6. Biological activities of hydrazone derivatives.

7. In vivo metabolism of N-phenyl-N'-(3,5-dimethylpyrazole-4-yl) thiourea in rats.

8. Some New Hydrazone Derivatives Bearing the 1,2,4-Triazole Moiety as Potential Antimycobacterial Agents.

9. Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates.