Literature DB >> 15230333

Absorption of ethyl 2-cyanoacrylate tissue adhesive.

Mehmet Kaplan1, Basak Oral, Sevim Rollas, Mustafa Sinan Kut, Mahmut Murat Demirtas.   

Abstract

The aim of this study was to investigate absorption of ethyl 2-cyanoacrylate glue when used as a tissue adhesive. Ethyl 2-cyanoacrylate was applied subcutaneously to four rats; its presence in blood and urine was investigated by using High Pressure Liquid Chromatography. Blood samples were drawn at baseline and after 2, 4, 6, 24, 48, 54, 78, 96 hours following application. Urine samples were obtained at baseline and after 4, 24, 48, 72, 96 hours. Administration of ethyl 2-cyanoacrylate resulted in its absorption of unchanged ethyl 2-cyanoacrylate and unknown metabolites, in plasma and urine.

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Year:  2004        PMID： 15230333     DOI： 10.1007/BF03190579

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  7 in total

1.  The in vivo metabolism of 5-(4-nitrophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats.

Authors:  E E Oruç; S Rollas; L Kabasakal; M K Uysal
Journal:  Drug Metabol Drug Interact       Date:  1999

2.  Avoidance of sternal nonunion with cyanoacrylate gluing.

Authors:  M M Demirtaş; M Akçar; S Sarikaya
Journal:  Ann Thorac Surg       Date:  1998-07       Impact factor: 4.330

3.  Review of facilitated approaches to vascular anastomosis surgery.

Authors:  P M Werker; M Kon
Journal:  Ann Thorac Surg       Date:  1997-06       Impact factor: 4.330

4.  Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice.

Authors:  Hongbing Wang; Brian Chanas; Burhan I Ghanayem
Journal:  Drug Metab Dispos       Date:  2002-08       Impact factor: 3.922

5.  Identification and comparison of the urinary metabolites of [1,2,3-13C3]acrylic acid and [1,2,3-13C3]propionic acid in the rat by homonuclear 13C nuclear magnetic resonance spectroscopy.

Authors:  S M Winter; G L Weber; P R Gooley; N E MacKenzie; I G Sipes
Journal:  Drug Metab Dispos       Date:  1992 Sep-Oct       Impact factor: 3.922

6.  Effects of dose, strain, and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel-exhaled metabolite.

Authors:  B I Ghanayem; I M Sanchez; L T Burka
Journal:  Drug Metab Dispos       Date:  1992 Sep-Oct       Impact factor: 3.922

7.  In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats.

Authors:  N N Gülerman; E E Oruç; F Kartal; S Rollas
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2000 Apr-Jun       Impact factor: 2.569
  7 in total

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