Literature DB >> 11106743

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA.

J Kwon1, K B Morshead, J R Guyon, R E Kingston, M A Oettinger.   

Abstract

The ordered assembly of immunoglobulin and TCR genes by V(D)J recombination depends on the regulated accessibility of individual loci. We show here that the histone tails and intrinsic nucleosome structure pose significant impediments to V(D)J cleavage. However, alterations to nucleosome structure via histone acetylation or by stable hSWI/SNF-dependent remodeling greatly increase the accessibility of nucleosomal DNA to V(D)J cleavage. Moreover, acetylation and hSWI/SNF remodeling can act in concert on an individual nucleosome to achieve levels of V(D)J cleavage approaching those observed on naked DNA. These results are consistent with a model in which regulated recruitment of chromatin modifying activities is involved in mediating the lineage and stage-specific control of V(D)J recombination.

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Year:  2000        PMID： 11106743     DOI： 10.1016/s1097-2765(00)00102-7

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  49 in total

1.  Direct imaging of human SWI/SNF-remodeled mono- and polynucleosomes by atomic force microscopy employing carbon nanotube tips.

Authors:  G R Schnitzler; C L Cheung; J H Hafner; A J Saurin; R E Kingston; C M Lieber
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

Review 2.  Regulation of antigen receptor gene assembly in lymphocytes.

Authors:  E M Oltz
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

Review 3.  RAG1 and RAG2 in V(D)J recombination and transposition.

Authors:  S D Fugmann
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

4.  Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.

Authors:  Juliet L Reid; Zarmik Moqtaderi; Kevin Struhl
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

5.  A multistep mechanism for the activation of rearrangement in the immune system.

Authors:  Yanhong Ji; Jianmin Zhang; Alfred Ian Lee; Howard Cedar; Yehudit Bergman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-11       Impact factor: 11.205

6.  Ordered assembly of the V(D)J synaptic complex ensures accurate recombination.

Authors:  Jessica M Jones; Martin Gellert
Journal:  EMBO J       Date:  2002-08-01       Impact factor: 11.598

7.  Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.

Authors:  Eric J Perkins; Barbara L Kee; Dale A Ramsden
Journal:  Nucleic Acids Res       Date:  2004-03-29       Impact factor: 16.971

Review 8.  Allelic exclusion of immunoglobulin genes: models and mechanisms.

Authors:  Christian Vettermann; Mark S Schlissel
Journal:  Immunol Rev       Date:  2010-09       Impact factor: 12.988

9.  Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences.

Authors:  Matthias Baumann; Adamantios Mamais; Fraser McBlane; Hua Xiao; Joan Boyes
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

10.  Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

Authors:  Sandhya R Pulivarthy; Mattia Lion; Guray Kuzu; Adam G W Matthews; Mark L Borowsky; John Morris; Robert E Kingston; Jonathan H Dennis; Michael Y Tolstorukov; Marjorie A Oettinger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205
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