BACKGROUND & AIMS:Glutamine is recognized as a conditionally essential amino acid. Recent studies indicate that glutamine-containing total parenteral nutrition improves nitrogen economy, enhances gastrointestinal and immune functions and shortens hospital stay. METHODS:Thirty-seven patients (19 w and 18 m; age 61. 4+/-10.4 years; BMI 23.7+/-2.8 kg/m(2)) following major abdominal surgery receiving an isonitrogenous isoenergetic TPN with or without alanyl-glutamine supplementation (0.5 g/kg BW/day), were evaluated in a double-blind, randomized, controlled trial over a five-day period by measuring nitrogen balance, selected biochemical parameters and length of hospital stay. RESULTS:Supplemental alanyl-glutamine improved the overall mean (-3.5+/-1.6 vs. -5.5+/-1. 4 g N;P<0.05) and cumulative nitrogen balance (-14.1+/-9.1 vs. -21.7+/-11.4 g N;P<0.05) compared with the isonitrogenous, isoenergetic standard regimen. Alanyl-glutamine normalized plasma glutamine concentration and reduced the length of hospital stay (12.8+/-2.6 vs. 17.5+/-6.4 days;P<0.05). CONCLUSIONS: The results of the study confirm that supplementation with synthetic alanyl-glutamine dipeptide is associated with cost containment due to shortened hospitalization and improved nitrogen economy. Copyright 2000 Harcourt Publishers Ltd.
RCT Entities:
BACKGROUND & AIMS:Glutamine is recognized as a conditionally essential amino acid. Recent studies indicate that glutamine-containing total parenteral nutrition improves nitrogen economy, enhances gastrointestinal and immune functions and shortens hospital stay. METHODS: Thirty-seven patients (19 w and 18 m; age 61. 4+/-10.4 years; BMI 23.7+/-2.8 kg/m(2)) following major abdominal surgery receiving an isonitrogenous isoenergetic TPN with or without alanyl-glutamine supplementation (0.5 g/kg BW/day), were evaluated in a double-blind, randomized, controlled trial over a five-day period by measuring nitrogen balance, selected biochemical parameters and length of hospital stay. RESULTS: Supplemental alanyl-glutamine improved the overall mean (-3.5+/-1.6 vs. -5.5+/-1. 4 g N;P<0.05) and cumulative nitrogen balance (-14.1+/-9.1 vs. -21.7+/-11.4 g N;P<0.05) compared with the isonitrogenous, isoenergetic standard regimen. Alanyl-glutamine normalized plasma glutamine concentration and reduced the length of hospital stay (12.8+/-2.6 vs. 17.5+/-6.4 days;P<0.05). CONCLUSIONS: The results of the study confirm that supplementation with synthetic alanyl-glutamine dipeptide is associated with cost containment due to shortened hospitalization and improved nitrogen economy. Copyright 2000 Harcourt Publishers Ltd.
Authors: Inga Tjäder; Olav Rooyackers; Ann-Marie Forsberg; Rokhsareh F Vesali; Peter J Garlick; Jan Wernerman Journal: Intensive Care Med Date: 2004-01-13 Impact factor: 17.440
Authors: Concepción F Estívariz; Daniel P Griffith; Menghua Luo; Elaina E Szeszycki; Niloofar Bazargan; Nisha Dave; Nicole M Daignault; Glen F Bergman; Therese McNally; Cindy H Battey; Celeste E Furr; Li Hao; James G Ramsay; Carolyn R Accardi; George A Cotsonis; Dean P Jones; John R Galloway; Thomas R Ziegler Journal: JPEN J Parenter Enteral Nutr Date: 2008-06-09 Impact factor: 4.016
Authors: Jon Pérez-Bárcena; Catalina Crespí; Verónica Regueiro; Pedro Marsé; Joan M Raurich; Jordi Ibáñez; Abelardo García de Lorenzo-Mateos; José A Bengoechea Journal: Crit Care Date: 2010-12-24 Impact factor: 9.097
Authors: A Weimann; Ch Ebener; S Holland-Cunz; K W Jauch; L Hausser; M Kemen; L Kraehenbuehl; E R Kuse; F Laengle Journal: Ger Med Sci Date: 2009-11-18
Authors: Peter J D Andrews; Alison Avenell; David W Noble; Marion K Campbell; Claire G Battison; Bernard L Croal; William G Simpson; John Norrie; Luke D Vale; Jonathon Cook; Robyn de Verteuil; Anne C Milne Journal: Trials Date: 2007-09-20 Impact factor: 2.279