Ya-Min Zheng1, Fei Li, Ming-Ming Zhang, Xiao-Ting Wu. 1. Department of General Surgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xuanwu District, Beijing 100053, China.
Abstract
AIM: To assess the clinical and economical validity of glutamine dipeptide supplemented to parenteral nutrition (PN) in patients undergoing abdominal surgery. METHODS: A meta-analysis of all the relevant randomized controlled trials (RCTs) was performed. The trials compared the standard PN and PN supplemented with glutamine dipeptide in abdominal surgery. RCTs were identified from the following electronic databases: the Cochrane Library, MEDLINE, EMBASE and ISI web of knowledge (SCI). The search was undertaken in April 2006. Literature references were checked by computer or hand at the same time. Clinical trials were extracted and evaluated by two reviewers independently. Statistical analysis was performed by RevMan4.2 software from Cochrane Collaboration. A P value of < 0.05 was considered statistically significant. RESULTS: Nine RCTs involving 373 patients were included. The combined results showed that glutamine dipeptide has a positive effect in improving postoperative cumulative nitrogen balance (weighted mean difference (WMD = 8.35, 95% CI [2.98, 13.71], P = 0.002), decreasing postoperative infectious morbidity (OR = 0.24, 95% CI [0.06, 0.93], P = 0.04), shortening the length of hospital stay (WMD= -3.55, 95% CI [-5.26, -1.84], P < 0.00001). No serious adverse effects were found. CONCLUSION: Postoperative PN supplemented with glutamine dipeptide is effective and safe to decrease the infectious rate, reduce the length of hospital stay and improve nitrogen balance in patients undergoing abdominal surgery. Further high quality trials in children and severe patients are required, and mortality and hospital cost should be considered in future RCTs with sufficient size and rigorous design.
AIM: To assess the clinical and economical validity of glutamine dipeptide supplemented to parenteral nutrition (PN) in patients undergoing abdominal surgery. METHODS: A meta-analysis of all the relevant randomized controlled trials (RCTs) was performed. The trials compared the standard PN and PN supplemented with glutamine dipeptide in abdominal surgery. RCTs were identified from the following electronic databases: the Cochrane Library, MEDLINE, EMBASE and ISI web of knowledge (SCI). The search was undertaken in April 2006. Literature references were checked by computer or hand at the same time. Clinical trials were extracted and evaluated by two reviewers independently. Statistical analysis was performed by RevMan4.2 software from Cochrane Collaboration. A P value of < 0.05 was considered statistically significant. RESULTS: Nine RCTs involving 373 patients were included. The combined results showed that glutamine dipeptide has a positive effect in improving postoperative cumulative nitrogen balance (weighted mean difference (WMD = 8.35, 95% CI [2.98, 13.71], P = 0.002), decreasing postoperative infectious morbidity (OR = 0.24, 95% CI [0.06, 0.93], P = 0.04), shortening the length of hospital stay (WMD= -3.55, 95% CI [-5.26, -1.84], P < 0.00001). No serious adverse effects were found. CONCLUSION: Postoperative PN supplemented with glutamine dipeptide is effective and safe to decrease the infectious rate, reduce the length of hospital stay and improve nitrogen balance in patients undergoing abdominal surgery. Further high quality trials in children and severe patients are required, and mortality and hospital cost should be considered in future RCTs with sufficient size and rigorous design.
Authors: N Mertes; C Schulzki; C Goeters; G Winde; S Benzing; K S Kuhn; H Van Aken; P Stehle; P Fürst Journal: Clin Nutr Date: 2000-12 Impact factor: 7.324
Authors: B J Morlion; P Stehle; P Wachtler; H P Siedhoff; M Köller; W König; P Fürst; C Puchstein Journal: Ann Surg Date: 1998-02 Impact factor: 12.969
Authors: M G O'Riordain; K C Fearon; J A Ross; P Rogers; J S Falconer; D C Bartolo; O J Garden; D C Carter Journal: Ann Surg Date: 1994-08 Impact factor: 12.969
Authors: Thomas R Ziegler; Addison K May; Gautam Hebbar; Kirk A Easley; Daniel P Griffith; Nisha Dave; Bryan R Collier; George A Cotsonis; Li Hao; Traci Leong; Amita K Manatunga; Eli S Rosenberg; Dean P Jones; Gregory S Martin; Gordon L Jensen; Harry C Sax; Kenneth A Kudsk; John R Galloway; Henry M Blumberg; Mary E Evans; Paul E Wischmeyer Journal: Ann Surg Date: 2016-04 Impact factor: 12.969
Authors: Karolina A P Wijnands; Tessy M R Castermans; Merel P J Hommen; Dennis M Meesters; Martijn Poeze Journal: Nutrients Date: 2015-02-18 Impact factor: 5.717
Authors: Paul E Wischmeyer; Rupinder Dhaliwal; Michele McCall; Thomas R Ziegler; Daren K Heyland Journal: Crit Care Date: 2014-04-18 Impact factor: 9.097