Inga Tjäder1, Olav Rooyackers2, Ann-Marie Forsberg2, Rokhsareh F Vesali2, Peter J Garlick3, Jan Wernerman2. 1. Department of Anesthesiology and Intensive Care, Clinical Metabolic Research Center, Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden. inga.tjader@hs.se. 2. Department of Anesthesiology and Intensive Care, Clinical Metabolic Research Center, Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden. 3. Department of Surgery, State University of New York, Stony Brook, New York, 11794-8191, USA.
Abstract
OBJECTIVE: To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism. DESIGN: A prospective, blinded, randomized study. SETTING: The general Intensive Care Unit (ICU) of a university hospital. PATIENTS: ICU patients with multiple organ failure (n=40), who were expected to stay in the unit for more than five days. INTERVENTION: Patients received 0, 0.28, 0.57 or 0.86 g of glutamine per kg bodyweight per day intravenously for five days as part of an isocaloric, isonitrogenous and isovolumetric diet. RESULTS: Plasma glutamine concentration responded to glutamine supplementation with normalization of plasma levels in a dose-dependent way, while free muscle glutamine concentration, as well as muscle protein synthesis and muscle protein content, did not change significantly. CONCLUSION:Intravenous glutamine supplementation to ICU patients for a period of five days resulted in normalization of plasma glutamine concentrations in a dose-dependent way whereas muscle glutamine concentrations were unaffected.
RCT Entities:
OBJECTIVE: To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism. DESIGN: A prospective, blinded, randomized study. SETTING: The general Intensive Care Unit (ICU) of a university hospital. PATIENTS: ICU patients with multiple organ failure (n=40), who were expected to stay in the unit for more than five days. INTERVENTION: Patients received 0, 0.28, 0.57 or 0.86 g of glutamine per kg bodyweight per day intravenously for five days as part of an isocaloric, isonitrogenous and isovolumetric diet. RESULTS: Plasma glutamine concentration responded to glutamine supplementation with normalization of plasma levels in a dose-dependent way, while free muscle glutamine concentration, as well as muscle protein synthesis and muscle protein content, did not change significantly. CONCLUSION: Intravenous glutamine supplementation to ICU patients for a period of five days resulted in normalization of plasma glutamine concentrations in a dose-dependent way whereas muscle glutamine concentrations were unaffected.
Authors: N Mertes; C Schulzki; C Goeters; G Winde; S Benzing; K S Kuhn; H Van Aken; P Stehle; P Fürst Journal: Clin Nutr Date: 2000-12 Impact factor: 7.324
Authors: Z M Jiang; L J Wang; Y Qi; T H Liu; M R Qiu; N F Yang; D W Wilmore Journal: JPEN J Parenter Enteral Nutr Date: 1993 Mar-Apr Impact factor: 4.016
Authors: Christiane Goeters; Anke Wenn; Norbert Mertes; Carola Wempe; Hugo Van Aken; Peter Stehle; Hans-Georg Bone Journal: Crit Care Med Date: 2002-09 Impact factor: 7.598
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerome Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker; Benoit Vallet Journal: Intensive Care Med Date: 2005-01-28 Impact factor: 17.440
Authors: Gabriëlla A M Ten Have; Mariëlle P K J Engelen; Robert R Wolfe; Nicolaas E P Deutz Journal: Am J Physiol Gastrointest Liver Physiol Date: 2019-04-12 Impact factor: 4.052
Authors: A Berg; B M Bellander; M Wanecek; L Gamrin; Ase Elving; O Rooyackers; U Ungerstedt; J Wernerman Journal: Intensive Care Med Date: 2006-09-23 Impact factor: 17.440