Literature DB >> 11090966

Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma.

J H Tsai1, Y S Hsieh, S J Kuo, S T Chen, S Y Yu, C Y Huang, A C Chang, Y W Wang, M T Tsai, J Y Liu.   

Abstract

This study was designed to investigate the alterations of individual protein kinase C (PKC) isoforms in human liver cancer. Surgical specimens of hepatocellular carcinoma and adjacent normal tissues were extracted into cytosolic and membranous fractions. The level of membrane-bound PKCalpha in the cancer tissue was significantly lower than that in the adjacent normal tissue and consistent with the change in PKC activity. In addition, there was a significant negative correlation between PKCalpha and tumor size. In both cytosolic and membrane fractions, levels of PKCdelta and PKCzeta was significantly higher in the cancer tissue than those in the adjacent normal liver tissue. The alterations in the PKC isoforms signify their roles in the hyperproliferation in liver cancer.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11090966     DOI： 10.1016/s0304-3835(00)00597-8

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  18 in total

Review 1.  Protein kinase C and cancer: what we know and what we do not.

Authors:  R Garg; L G Benedetti; M B Abera; H Wang; M Abba; M G Kazanietz
Journal:  Oncogene       Date:  2013-12-16       Impact factor: 9.867

2.  Par6 is phosphorylated by aPKC to facilitate EMT.

Authors:  Adrian Gunaratne; Gianni M Di Guglielmo
Journal:  Cell Adh Migr       Date:  2013-07-09       Impact factor: 3.405

3.  Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.

Authors:  Hsin-Hsin Kao; Chao-Jung Wu; Shen-Jeu Won; Jyh-Wei Shin; Hsiao-Sheng Liu; Chun-Li Su
Journal:  Plant Foods Hum Nutr       Date:  2011-06       Impact factor: 3.921

4.  Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.

Authors:  Huajun Jin; Arthi Kanthasamy; Vellareddy Anantharam; Ajay Rana; Anumantha G Kanthasamy
Journal:  J Biol Chem       Date:  2011-04-05       Impact factor: 5.157

5.  Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Authors:  Jennifer M Symonds; Angela M Ohm; Cristan J Carter; Lynn E Heasley; Theresa A Boyle; Wilbur A Franklin; Mary E Reyland
Journal:  Cancer Res       Date:  2011-02-18       Impact factor: 12.701

6.  Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors.

Authors:  Elaine M Reno; James M Haughian; Irina K Dimitrova; Twila A Jackson; Kenneth R Shroyer; Andrew P Bradford
Journal:  Hum Pathol       Date:  2007-10-24       Impact factor: 3.466

7.  Expression of protein kinase C family in human hepatocellular carcinoma.

Authors:  Hsiu-Chin Lu; Fen-Pi Chou; Kun-Tu Yeh; Ya-Sian Chang; Nicholas C Hsu; Jan-Gowth Chang
Journal:  Pathol Oncol Res       Date:  2009-12-01       Impact factor: 3.201

Review 8.  Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

Authors:  Ling Huang; Senthil K Muthuswamy
Journal:  Curr Opin Genet Dev       Date:  2010-01-21       Impact factor: 5.578

Review 9.  Apico-basal polarity complex and cancer.

Authors:  Mohammed Khursheed; Murali Dharan Bashyam
Journal:  J Biosci       Date:  2014-03       Impact factor: 1.826

10.  Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

Authors:  Ping Yi; Qin Feng; Larbi Amazit; David M Lonard; Sophia Y Tsai; Ming-Jer Tsai; Bert W O'Malley
Journal:  Mol Cell       Date:  2008-02-29       Impact factor: 17.970
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.