Literature DB >> 20093003

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

Ling Huang1, Senthil K Muthuswamy.   

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20093003      PMCID： PMC3015045          DOI： 10.1016/j.gde.2009.12.001

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  82 in total

1.  Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression.

Authors:  Xuefeng Lu; Xiujing Feng; Xiaobo Man; Guang Yang; Liang Tang; Dan Du; Fan Zhang; Haixin Yuan; Qin Huang; Zhe Zhang; Yinkun Liu; Dennis Strand; Zhengjun Chen
Journal:  Clin Cancer Res       Date:  2009-05-15       Impact factor: 12.531

2.  Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

Authors:  Lixing Zhan; Avi Rosenberg; Kenneth C Bergami; Min Yu; Zhenyu Xuan; Aron B Jaffe; Craig Allred; Senthil K Muthuswamy
Journal:  Cell       Date:  2008-11-28       Impact factor: 41.582

Review 3.  Planar cell polarity signaling: from fly development to human disease.

Authors:  Matias Simons; Marek Mlodzik
Journal:  Annu Rev Genet       Date:  2008       Impact factor: 16.830

4.  Expression of P-aPKC-iota, E-cadherin, and beta-catenin related to invasion and metastasis in hepatocellular carcinoma.

Authors:  Guang-Sheng Du; Jian-Ming Wang; Jin-Xi Lu; Qiang Li; Chao-Qun Ma; Ji-Tao Du; Sheng-Quan Zou
Journal:  Ann Surg Oncol       Date:  2009-03-17       Impact factor: 5.344

Review 5.  Crosstalk between small GTPases and polarity proteins in cell polarization.

Authors:  Sandra Iden; John G Collard
Journal:  Nat Rev Mol Cell Biol       Date:  2008-11       Impact factor: 94.444

6.  The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.

Authors:  Marissa E Nolan; Victoria Aranda; Sangjun Lee; Balasubramanian Lakshmi; Srinjan Basu; D Craig Allred; Senthil K Muthuswamy
Journal:  Cancer Res       Date:  2008-10-15       Impact factor: 12.701

7.  Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.

Authors:  L E Dow; I A Elsum; C L King; K M Kinross; H E Richardson; P O Humbert
Journal:  Oncogene       Date:  2008-07-21       Impact factor: 9.867

Review 8.  Polarity proteins in migration and invasion.

Authors:  S Etienne-Manneville
Journal:  Oncogene       Date:  2008-11-24       Impact factor: 9.867

9.  Transcriptome sequencing to detect gene fusions in cancer.

Authors:  Christopher A Maher; Chandan Kumar-Sinha; Xuhong Cao; Shanker Kalyana-Sundaram; Bo Han; Xiaojun Jing; Lee Sam; Terrence Barrette; Nallasivam Palanisamy; Arul M Chinnaiyan
Journal:  Nature       Date:  2009-01-11       Impact factor: 49.962

10.  The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer.

Authors:  S Al-Saad; K Al-Shibli; T Donnem; M Persson; R M Bremnes; L-T Busund
Journal:  Br J Cancer       Date:  2008-10-14       Impact factor: 7.640
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  62 in total

Review 1.  Epithelial cell polarity, stem cells and cancer.

Authors:  Fernando Martin-Belmonte; Mirna Perez-Moreno
Journal:  Nat Rev Cancer       Date:  2011-12-15       Impact factor: 60.716

2.  Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.

Authors:  Andrew J Ewald; Robert J Huebner; Hildur Palsdottir; Jessie K Lee; Melissa J Perez; Danielle M Jorgens; Andrew N Tauscher; Kevin J Cheung; Zena Werb; Manfred Auer
Journal:  J Cell Sci       Date:  2012-02-17       Impact factor: 5.285

3.  Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

Authors:  Johanna I Partanen; Topi A Tervonen; Mikko Myllynen; Essi Lind; Misa Imai; Pekka Katajisto; Gerrit J P Dijkgraaf; Panu E Kovanen; Tomi P Mäkelä; Zena Werb; Juha Klefström
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-20       Impact factor: 11.205

4.  The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.

Authors:  William P Ranahan; Zhang Han; Whitney Smith-Kinnaman; Sarah C Nabinger; Brigitte Heller; Britney-Shea Herbert; Rebecca Chan; Clark D Wells
Journal:  Cancer Res       Date:  2011-02-01       Impact factor: 12.701

Review 5.  Atypical protein kinase Cι as a human oncogene and therapeutic target.

Authors:  Peter J Parker; Verline Justilien; Philippe Riou; Mark Linch; Alan P Fields
Journal:  Biochem Pharmacol       Date:  2013-11-11       Impact factor: 5.858

6.  Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.

Authors:  Christine Mehner; Erin Miller; Davitte Khauv; Aziza Nassar; Ann L Oberg; William R Bamlet; Lizhi Zhang; Jens Waldmann; Evette S Radisky; Howard C Crawford; Derek C Radisky
Journal:  Mol Cancer Res       Date:  2014-05-21       Impact factor: 5.852

7.  Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis.

Authors:  Joanne Durgan; Noriko Kaji; Dan Jin; Alan Hall
Journal:  J Biol Chem       Date:  2011-02-07       Impact factor: 5.157

Review 8.  Control of cell migration through mRNA localization and local translation.

Authors:  Guoning Liao; Lisa Mingle; Livingston Van De Water; Gang Liu
Journal:  Wiley Interdiscip Rev RNA       Date:  2014-09-28       Impact factor: 9.957

9.  Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells.

Authors:  Robert J Huebner; Terry Lechler; Andrew J Ewald
Journal:  Development       Date:  2014-03       Impact factor: 6.868

10.  Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly.

Authors:  Hui Wang; Sam Lacoche; Ling Huang; Bin Xue; Senthil K Muthuswamy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205
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