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Literature DB >> 19949911

Expression of protein kinase C family in human hepatocellular carcinoma.

Hsiu-Chin Lu¹, Fen-Pi Chou, Kun-Tu Yeh, Ya-Sian Chang, Nicholas C Hsu, Jan-Gowth Chang.

Abstract

Protein kinase Cs (PKCs) play important roles in signal transduction, cell regulation, and tumor formation. In the present study, we analyzed the expression of PKCs in human hepatocellular carcinoma (HCC) tissues and explored their roles in the development of HCC. Real-time quantitative PCR and immunohistochemistry showed that PKCbeta and PKCtheta were down-regulated in HCC tissues. Reduced expression of PKCtheta is well correlated with the grade of cancer cells (p = 0.009), and the down-regulated expression of PKCbetaII is associated with HBV infection (p = 0.035). Our findings suggest particular roles of the two PKC isoenzymes in the hepatocarcinogenesis of human HCC.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19949911 DOI： 10.1007/s12253-009-9228-z

Source DB: PubMed Journal: Pathol Oncol Res ISSN： 1219-4956 Impact factor: 3.201

62 in total

1. Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors.

Authors: R Koren; L Langzam; A Paz; P M Livne; R Gal; S R Sampson
Journal: Appl Immunohistochem Mol Morphol Date: 2000-06

2. Molecular pathogenesis of human hepatocellular carcinoma.

Authors: Snorri S Thorgeirsson; Joe W Grisham
Journal: Nat Genet Date: 2002-08 Impact factor: 38.330

3. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.

Authors: H A EDMONDSON; P E STEINER
Journal: Cancer Date: 1954-05 Impact factor: 6.860

4. The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways.

Authors: Gilles Despouy; Marjorie Joiner; Emilie Le Toriellec; Robert Weil; Marc Henri Stern
Journal: Blood Date: 2007-09-10 Impact factor: 22.113

5. Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer.

Authors: D B Fournier; M Chisamore; J R Lurain; A W Rademaker; V C Jordan; D A Tonetti
Journal: Gynecol Oncol Date: 2001-06 Impact factor: 5.482

6. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression.

Authors: A Besson; V W Yong
Journal: Mol Cell Biol Date: 2000-07 Impact factor: 4.272

7. Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.

Authors: B Scaglione-Sewell; C Abraham; M Bissonnette; S F Skarosi; J Hart; N O Davidson; R K Wali; B H Davis; M Sitrin; T A Brasitus
Journal: Cancer Res Date: 1998-03-01 Impact factor: 12.701

8. Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival.

Authors: C Martínez-Gimeno; M T Díaz-Meco; I Domínguez; J Moscat
Journal: Head Neck Date: 1995 Nov-Dec Impact factor: 3.147

9. Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.

Authors: Kyung-Sun Heo; Dong-Uk Kim; Lila Kim; Miyoung Nam; Seung-Tae Baek; Song-Kyu Park; Youngwoo Park; Chang-Seon Myung; Sung-Ook Hwang; Kwang-Lae Hoe
Journal: Biochem Biophys Res Commun Date: 2008-01-22 Impact factor: 3.575