Literature DB >> 1108776

Minimal inhibitory concentration of dapsone for Mycobacterium leprae in rats.

J H Peters, G R Gordon, J F Murray, A H Fieldsteel, L Levy.   

Abstract

To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.

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Year:  1975        PMID： 1108776      PMCID： PMC429419          DOI： 10.1128/AAC.8.5.551

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  LIMITED MULTIPLICATION OF ACID-FAST BACILLI IN THE FOOT-PADS OF MICE INOCULATED WITH MYCOBACTERIUM LEPRAE.

Authors:  R J REES
Journal:  Br J Exp Pathol       Date:  1964-04

2.  Chromatographic-fluorometric analysis of antileprotic sulfones.

Authors:  J F Murray; G R Gordon; C C Gulledge; J H Peters
Journal:  J Chromatogr       Date:  1975-04-09

3.  Letter: Sensitivity of Mycobacterium leprae to dapsone, studied in the rat.

Authors:  S R Pattyn; G Verdoolaeghe-Van Loo
Journal:  Int J Lepr Other Mycobact Dis       Date:  1974 Jan-Mar

4.  Potential antileprotic agents. 1. Inhibition of a model mycobacterial system by diaryl sulfones.

Authors:  W T Colwell; G Chan; V H Brown; J I DeGraw; J H Peters; N E Morrison
Journal:  J Med Chem       Date:  1974-01       Impact factor: 7.446

5.  Disposition of the antileprosy drug, dapsone, in the mouse.

Authors:  L Levy; J T Biggs; G R Gordon; J H Peters
Journal:  Proc Soc Exp Biol Med       Date:  1972-07

6.  Gerhard Henrik Armauer Hansen. What did he see and when?

Authors:  W H Feldman
Journal:  Int J Lepr       Date:  1965 Jul-Sep

7.  The polymorphic acetylation of dapsone in man.

Authors:  R Gelber; J H Peters; G R Gordon; A J Glazko; L Levy
Journal:  Clin Pharmacol Ther       Date:  1971 Mar-Apr       Impact factor: 6.875

Review 8.  A survey of the drugs with activity against M. leprae in mice.

Authors:  C C Shepard
Journal:  Int J Lepr Other Mycobact Dis       Date:  1971 Apr-Jun

9.  Effect of neonatal thymectomy and antithymocytic serum on susceptibility of rats to mycobacterium leprae infection.

Authors:  A H Fieldsteel; A H McIntosh
Journal:  Proc Soc Exp Biol Med       Date:  1971-11

10.  Studies on the determination of the minimal inhibitory concentration of 4,4'-diamino-diphenyl-sulphone (Dapsone, DDS) against Mycobacterium leprae.

Authors:  G A Ellard; P T Gammon; R J Rees; M F Waters
Journal:  Lepr Rev       Date:  1971-06       Impact factor: 0.537
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  4 in total

1.  Activity of derivatives and analogs of dapsone against Mycobacterium leprae.

Authors:  L Levy
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

2.  Bactericidal action of dapsone against Mycobacterium leprae in mice.

Authors:  L Levy
Journal:  Antimicrob Agents Chemother       Date:  1976-04       Impact factor: 5.191

3.  Rapid, radiolabeled macrophage culture method for detection of dapsone-resistant Mycobacterium leprae.

Authors:  I Nath; H K Prasad; M Sathish; K V Desikan; P S Seshadri; C G Iyer
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

4.  Antitubercular effect of 8-[(4-Chloro phenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One in guinea pigs.

Authors:  Parvati B Patel; Tejas K Patel; Seema N Baxi; Hemangini R Acharya; Chandrabhanu Tripathi
Journal:  J Pharmacol Pharmacother       Date:  2011-10
  4 in total

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