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Literature DB >> 727767

Activity of derivatives and analogs of dapsone against Mycobacterium leprae.

Abstract

Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.

Entities: Chemical Species

Mesh：

Substances：
Dapsone

Year: 1978 PMID： 727767 PMCID： PMC352553 DOI： 10.1128/AAC.14.5.791

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. THE IN VIRTO ACTIVITY OF 4,4'-DIAMINODIPHENYL SULFONE AGAINST VARIOUS ACID-FAST MICROORGANISMS.

Authors: A G KARLSON
Journal: Int J Lepr Date: 1963 Apr-Jun

2. The action of dapsone on a susceptible strain of Mycobacterium kansasii.

Authors: M Panitch; L Levy
Journal: Lepr Rev Date: 1978-06 Impact factor: 0.537

3. The minimal inhibitory concentrations of sulphadimethozine and sulphadoxine against Mycobacterium leprae.

Authors: G A Ellard; P T Gammon; R J Rees
Journal: Lepr Rev Date: 1970-10 Impact factor: 0.537

4. Further experience with the kinetic method for the study of drugs against Mycobacterium leprae in mice. Activities of DDS, DFD, ethionamide, capreomycin and PAM 1392.

Authors: C C Shepard
Journal: Int J Lepr Other Mycobact Dis Date: 1969 Oct-Dec

5. Antimicrobial therapy of experimental human leprosy (Myco. leprae) infection in the mouse foot pad.

Authors: J M Gaugas
Journal: Lepr Rev Date: 1967-10 Impact factor: 0.537

6. A method for counting acid-fast bacteria.

Authors: C C Shepard; D H McRae
Journal: Int J Lepr Other Mycobact Dis Date: 1968 Jan-Mar

7. Disposition of the antileprosy drug, dapsone, in the mouse.

Authors: L Levy; J T Biggs; G R Gordon; J H Peters
Journal: Proc Soc Exp Biol Med Date: 1972-07

8. Activity of repository sulfones against Mycobacterium leprae in mice.

Authors: C C Shepard
Journal: Proc Soc Exp Biol Med Date: 1967-02

9. Absorption, metabolism and excretion of di(rho-aminophenyl) sulphone (dapsone) and di(rho-aminophenyl) sulphoxide in man.

Authors: G A Ellard
Journal: Br J Pharmacol Chemother Date: 1966-01

10. Application of spectrophotofluorometric procedures to some problems in Mycobacterium leprae infections in mice and man treated with dapsone (DDS), diacetyl-DDS (DADDS), and di-formyl-DDS (DFD).

Authors: T Ozawa; C C Shepard; A B Karat
Journal: Am J Trop Med Hyg Date: 1971-03 Impact factor: 2.345

2 in total

1. Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis.

Authors: D L Williams; T L Pittman; T P Gillis; M Matsuoka; Y Kashiwabara
Journal: J Clin Microbiol Date: 2001-06 Impact factor: 5.948

2. Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance.

Authors: D L Williams; L Spring; E Harris; P Roche; T P Gillis
Journal: Antimicrob Agents Chemother Date: 2000-06 Impact factor: 5.191

2 in total