Literature DB >> 11071942

DNA-triplex stabilizing properties of 8-aminoguanine.

R Soliva1, R Güimil García, J R Blas, R Eritja, J L Asensio, C González, F J Luque, M Orozco.   

Abstract

A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and demonstrate that few changes are found in the structure of the triplex due to the presence of this modified base.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11071942      PMCID： PMC113881          DOI： 10.1093/nar/28.22.4531

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  36 in total

1.  Triple helix-mediated single-site enzymatic cleavage of megabase genomic DNA.

Authors:  S A Strobel; P B Dervan
Journal:  Methods Enzymol       Date:  1992       Impact factor: 1.600

Review 2.  Specific regulation of gene expression by antisense, sense and antigene nucleic acids.

Authors:  C Hélène; J J Toulmé
Journal:  Biochim Biophys Acta       Date:  1990-06-21

3.  Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine.

Authors:  R Güimil García; A Bachi; R Eritja; F J Luque; M Orozco
Journal:  Bioorg Med Chem Lett       Date:  1998-11-03       Impact factor: 2.823

4.  Solution structure of an intramolecular DNA triplex containing 5-(1-propynyl)-2'-deoxyuridine residues in the third strand.

Authors:  A K Phipps; M Tarköy; P Schultze; J Feigon
Journal:  Biochemistry       Date:  1998-04-28       Impact factor: 3.162

5.  Solution structure of an intramolecular DNA triplex containing an N7-glycosylated guanine which mimics a protonated cytosine.

Authors:  K M Koshlap; P Schultze; H Brunar; P B Dervan; J Feigon
Journal:  Biochemistry       Date:  1997-03-04       Impact factor: 3.162

6.  Thermodynamics of an intramolecular DNA triple helix: a calorimetric and spectroscopic study of the pH and salt dependence of thermally induced structural transitions.

Authors:  G E Plum; K J Breslauer
Journal:  J Mol Biol       Date:  1995-05-05       Impact factor: 5.469

7.  1H NMR spectroscopy of DNA triplexes and quadruplexes.

Authors:  J Feigon; K M Koshlap; F W Smith
Journal:  Methods Enzymol       Date:  1995       Impact factor: 1.600

8.  A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules.

Authors:  A Kumar; R R Ernst; K Wüthrich
Journal:  Biochem Biophys Res Commun       Date:  1980-07-16       Impact factor: 3.575

9.  Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites.

Authors:  M Grigoriev; D Praseuth; A L Guieysse; P Robin; N T Thuong; C Hélène; A Harel-Bellan
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

10.  Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3.

Authors:  E Wang; K M Koshlap; P Gillespie; P B Dervan; J Feigon
Journal:  J Mol Biol       Date:  1996-04-19       Impact factor: 5.469
View more
  10 in total

Review 1.  New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.

Authors:  Huiqing Zhou; Bradley J Hintze; Isaac J Kimsey; Bharathwaj Sathyamoorthy; Shan Yang; Jane S Richardson; Hashim M Al-Hashimi
Journal:  Nucleic Acids Res       Date:  2015-03-26       Impact factor: 16.971

2.  The effect of amino groups on the stability of DNA duplexes and triplexes based on purines derived from inosine.

Authors:  E Cubero; R Güimil-García; F J Luque; R Eritja; M Orozco
Journal:  Nucleic Acids Res       Date:  2001-06-15       Impact factor: 16.971

3.  Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.

Authors:  Bharathwaj Sathyamoorthy; Honglue Shi; Huiqing Zhou; Yi Xue; Atul Rangadurai; Dawn K Merriman; Hashim M Al-Hashimi
Journal:  Nucleic Acids Res       Date:  2017-05-19       Impact factor: 16.971

4.  Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates.

Authors:  Deirdre Murphy; Ramon Eritja; Gareth Redmond
Journal:  Nucleic Acids Res       Date:  2004-04-23       Impact factor: 16.971

5.  Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines.

Authors:  Anna Aviñó; Miriam Frieden; Juan Carlos Morales; Beatriz García de la Torre; Ramón Güimil García; Ferran Azorín; José Luis Gelpí; Modesto Orozco; Carlos González; Ramon Eritja
Journal:  Nucleic Acids Res       Date:  2002-06-15       Impact factor: 16.971

6.  Structural properties of g,t-parallel duplexes.

Authors:  Anna Aviñó; Elena Cubero; Raimundo Gargallo; Carlos González; Modesto Orozco; Ramon Eritja
Journal:  J Nucleic Acids       Date:  2010-02-21

7.  Recombination R-triplex: H-bonds contribution to stability as revealed with minor base substitutions for adenine.

Authors:  Anna K Shchyolkina; Dmitry N Kaluzhny; Donna J Arndt-Jovin; Thomas M Jovin; Victor B Zhurkin
Journal:  Nucleic Acids Res       Date:  2006-06-23       Impact factor: 16.971

8.  Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine.

Authors:  Lamia L G Al-Mahamad
Journal:  Heliyon       Date:  2019-05-15

9.  Dynamical treatment of charge transfer through duplex nucleic acids containing modified adenines.

Authors:  Giorgia Brancolini; Agostino Migliore; Stefano Corni; Miguel Fuentes-Cabrera; F Javier Luque; Rosa Di Felice
Journal:  ACS Nano       Date:  2013-09-30       Impact factor: 15.881

10.  Synthesis and structural characterization of stable branched DNA g-quadruplexes using the trebler phosphoramidite.

Authors:  Rubén Ferreira; Margarita Alvira; Anna Aviñó; Irene Gómez-Pinto; Carlos González; Valérie Gabelica; Ramon Eritja
Journal:  ChemistryOpen       Date:  2012-04       Impact factor: 2.911
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.