Literature DB >> 12060677

Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines.

Anna Aviñó1, Miriam Frieden, Juan Carlos Morales, Beatriz García de la Torre, Ramón Güimil García, Ferran Azorín, José Luis Gelpí, Modesto Orozco, Carlos González, Ramon Eritja.   

Abstract

Parallel-stranded hairpins with a polypyrimidine sequence linked to a complementary purine carrying 8-aminopurines such as 8-aminoadenine, 8-aminoguanine and 8-aminohypoxanthine bind polypyrimidine sequences complementary (in an antiparallel sense) to the purine part by a triple helix. The relative stabilities of triplexes were assessed by UV-absorption melting experiments as a function of pH and salt concentration. Hairpins carrying 8-aminopurines give very stable triple helical structures even at neutral pH, as confirmed by gel-shift experiments, circular dichroism and nuclear magnetic resonance spectroscopy. The modified hairpins may be redesigned to cope with small interruptions in the polypyrimidine target sequence.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12060677      PMCID： PMC117286          DOI： 10.1093/nar/gkf374

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  23 in total

Review 1.  Towards mixed sequence recognition by triple helix formation.

Authors:  D M Gowers; K R Fox
Journal:  Nucleic Acids Res       Date:  1999-04-01       Impact factor: 16.971

2.  DNA-triplex stabilizing properties of 8-aminoguanine.

Authors:  R Soliva; R Güimil García; J R Blas; R Eritja; J L Asensio; C González; F J Luque; M Orozco
Journal:  Nucleic Acids Res       Date:  2000-11-15       Impact factor: 16.971

3.  pH and cation effects on the properties of parallel pyrimidine motif DNA triplexes.

Authors:  N Sugimoto; P Wu; H Hara; Y Kawamoto
Journal:  Biochemistry       Date:  2001-08-07       Impact factor: 3.162

Review 4.  Parallel-stranded duplex DNA.

Authors:  K Rippe; T M Jovin
Journal:  Methods Enzymol       Date:  1992       Impact factor: 1.600

Review 5.  Triplex DNA: fundamentals, advances, and potential applications for gene therapy.

Authors:  P P Chan; P M Glazer
Journal:  J Mol Med (Berl)       Date:  1997-04       Impact factor: 4.599

6.  The effect of amino groups on the stability of DNA duplexes and triplexes based on purines derived from inosine.

Authors:  E Cubero; R Güimil-García; F J Luque; R Eritja; M Orozco
Journal:  Nucleic Acids Res       Date:  2001-06-15       Impact factor: 16.971

7.  A modified version of the Cornell et al. force field with improved sugar pucker phases and helical repeat.

Authors:  T E Cheatham; P Cieplak; P A Kollman
Journal:  J Biomol Struct Dyn       Date:  1999-02

8.  Triple helix formation by oligopurine-oligopyrimidine DNA fragments. Electrophoretic and thermodynamic behavior.

Authors:  G Manzini; L E Xodo; D Gasparotto; F Quadrifoglio; G A van der Marel; J H van Boom
Journal:  J Mol Biol       Date:  1990-06-20       Impact factor: 5.469

9.  Effect of 5-methylcytosine on the stability of triple-stranded DNA--a thermodynamic study.

Authors:  L E Xodo; G Manzini; F Quadrifoglio; G A van der Marel; J H van Boom
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

10.  Parallel stranded DNA.

Authors:  J H van de Sande; N B Ramsing; M W Germann; W Elhorst; B W Kalisch; E von Kitzing; R T Pon; R C Clegg; T M Jovin
Journal:  Science       Date:  1988-07-29       Impact factor: 47.728
View more
  11 in total

1.  Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates.

Authors:  Deirdre Murphy; Ramon Eritja; Gareth Redmond
Journal:  Nucleic Acids Res       Date:  2004-04-23       Impact factor: 16.971

2.  Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes.

Authors:  M Cristina de Almagro; Silvia Coma; Véronique Noé; Carlos J Ciudad
Journal:  J Biol Chem       Date:  2009-03-03       Impact factor: 5.157

3.  Conformation and protein interactions of intramolecular DNA and phosphorothioate four-way junctions.

Authors:  Maria Troisi; Mitchell Klein; Andrew C Smith; Gaston Moorhead; Yonatan Kebede; Raymond Huang; Elliott Parker; Hector Herrada; Elizabeth Wade; Samara Smith; Payson Broome; Jonah Halsell; Louis Estevez; Anthony J Bell
Journal:  Exp Biol Med (Maywood)       Date:  2020-12-20

4.  Targeting duplex DNA with chimeric α,β-triplex-forming oligonucleotides.

Authors:  N A Kolganova; A K Shchyolkina; A V Chudinov; A S Zasedatelev; V L Florentiev; E N Timofeev
Journal:  Nucleic Acids Res       Date:  2012-05-27       Impact factor: 16.971

5.  Structural properties of g,t-parallel duplexes.

Authors:  Anna Aviñó; Elena Cubero; Raimundo Gargallo; Carlos González; Modesto Orozco; Ramon Eritja
Journal:  J Nucleic Acids       Date:  2010-02-21

6.  Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method.

Authors:  Laura G Carrascosa; S Gómez-Montes; A Aviñó; A Nadal; M Pla; R Eritja; L M Lechuga
Journal:  Nucleic Acids Res       Date:  2012-01-12       Impact factor: 16.971

7.  Alternative DNA structure formation in the mutagenic human c-MYC promoter.

Authors:  Imee Marie A Del Mundo; Maha Zewail-Foote; Sean M Kerwin; Karen M Vasquez
Journal:  Nucleic Acids Res       Date:  2017-05-05       Impact factor: 16.971

8.  Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine.

Authors:  Lamia L G Al-Mahamad
Journal:  Heliyon       Date:  2019-05-15

9.  Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells.

Authors:  Gizem Bener; Alex J Félix; Cristina Sánchez de Diego; Isabel Pascual Fabregat; Carlos J Ciudad; Véronique Noé
Journal:  BMC Immunol       Date:  2016-09-26       Impact factor: 3.615

10.  Triplex Hybridization-Based Nanosystem for the Rapid Screening of Pneumocystis Pneumonia in Clinical Samples.

Authors:  Luis Pla; Anna Aviñó; Ramón Eritja; Alba Ruiz-Gaitán; Javier Pemán; Vicente Friaza; Enrique J Calderón; Elena Aznar; Ramón Martínez-Máñez; Sara Santiago-Felipe
Journal:  J Fungi (Basel)       Date:  2020-11-17
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.