Literature DB >> 6769698

Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro.

B Ziegler, B Wilke, M Ziegler, S Schmidt, H Zühlke.   

Abstract

Isolated islets from C57Bl/6J mice exposed to 10 mmoles/l glucose supplemented with 5 micrograms/ml glibenclamide for 48 h released significantly less insulin in the subsequent short-time incubation than untreated controls (without glibenclamide), whereas insulin biosynthesis was not suppressed by glibenclamide treatment.

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Year:  1980        PMID： 6769698     DOI： 10.1007/bf01975151

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  The stimulus-secretion coupling of glucose-induced insulin release. 8. Combined effects of glucose and sulfonylureas.

Authors:  W J Malaisse; M Mahy; G R Brisson; F Malaisse-Lagae
Journal:  Eur J Clin Invest       Date:  1972-01       Impact factor: 4.686

2.  Long-term actions of sulfonylureas on (pro-) insulin biosynthesis and secretion: I. Lack of evidence for a compensatory increase in (pro-) insulin biosynthesis after exposure of isolated pancreatic rat islets to tolbutamide and glibenclamide in vitro.

Authors:  H Schatz; D Steinle; E F Pfeiffer
Journal:  Horm Metab Res       Date:  1977-11       Impact factor: 2.936

3.  Tolbutamide-induced changes of the DNA, protein and insulin content and the secretory activity of isolated rat pancreatic islets.

Authors:  P Schauder; H Frerichs
Journal:  Diabetologia       Date:  1975-08       Impact factor: 10.122

4.  Onset and reversibility of changes in secretory function and composition of isolated rat pancreatic islets following long-term administrationof high or low tolbutamide doses.

Authors:  P Schauder; J Arends; H Frerichs
Journal:  Metabolism       Date:  1977-01       Impact factor: 8.694

5.  Successful cultivation of isolated islets of Langerhans without attachment: relationship between Glucose- and theophylline-induced insulin release and insulin content in rats islets after cultivation.

Authors:  B Ziegler; H J Hahn; M Ziegler; H Fiedler
Journal:  Endokrinologie       Date:  1977-02

6.  The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.

Authors:  H Schatz; V Maier; M Hinz; C Nierle; E F Pfeiffer
Journal:  FEBS Lett       Date:  1972-10-01       Impact factor: 4.124

7.  An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.

Authors:  J C Dunbar; P P Foà
Journal:  Diabetologia       Date:  1974-02       Impact factor: 10.122

8.  Changes in glucose-stimulated insulin secretion after long-term treatment of C57BL mice with glibenclamide.

Authors:  S Schmidt; B Wilke; B Ziegler; H Jahr; H Zühlke
Journal:  Endokrinologie       Date:  1980-10
  8 in total

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