Literature DB >> 785375

Cytochalasin B: evidence for a membrane-directed action in B-cells from rat pancreatic islets.

P Schauder, H Frerichs.   

Abstract

In the presence of cytochalasin B (CCB) concentrations from 50 to 200 mug/ml there is a dose-dependant inhibition of insulin release from isolated rat pancreatic islets. Inhibition is unspecific with respect to glucose, leucine, tolbutamide or theophylline and is reversible. Production of 14CO2 from uniformly labeled D-glucose is decreased. Islets pretreated with an high (200 mug/ml) or low (10 mug/ml) CCB dose release more insulin in response to a subsequent glucose or leucine stimulus in a CCB free medium compared with controls. The data are compatible with a membrane-directed action of CCB.

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Year:  1976        PMID： 785375     DOI： 10.1007/bf01062918

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  21 in total

1.  Dynamics of insulin release and microtubular-microfilamentous system. VII. Do microfilaments provide the motive force for the translocation and extrusion of beta granules?

Authors:  E Van Obberghen; G Somers; G Devis; M Ravazzola; F Malaisse-Lagae; L Orci; W J Malaisse
Journal:  Diabetes       Date:  1975-10       Impact factor: 9.461

2.  Effects of L-leucine and alpha-ketoisocaproic acid upon insulin secretion and metabolism of isolated pancreatic islets.

Authors:  U Panten; E v. Kriegstein; W Poser; J Schönborn; A Hasselblatt
Journal:  FEBS Lett       Date:  1972-02-01       Impact factor: 4.124

3.  Cytochalasin B: inhibition of glucose-induced insulin release from isolated rat pancreatic islets.

Authors:  P Schauder; H Frerichs
Journal:  Diabetologia       Date:  1974-02       Impact factor: 10.122

4.  Dissociation of the insulin releasing and the metabolic functions of hexoses in islets of Langerhans.

Authors:  F M Matschinsky; J Ellerman
Journal:  Biochem Biophys Res Commun       Date:  1973-01-23       Impact factor: 3.575

5.  Pancreatic beta-cell web: its possible role in insulin secretion.

Authors:  L Orci; K H Gabbay; W J Malaisse
Journal:  Science       Date:  1972-03-10       Impact factor: 47.728

6.  Inhibition of the transport of several hexoses in mammalian cells by cytochalasin B.

Authors:  S B Mizel; L Wilson
Journal:  J Biol Chem       Date:  1972-06-25       Impact factor: 5.157

7.  Cytokinesis and cytochalasin-induced furrow regression in the first-cleavage zygote of Xenopus laevis.

Authors:  J G Bluemink
Journal:  Z Zellforsch Mikrosk Anat       Date:  1971

8.  Binding of cytochalasin B to a red cell membrane protein.

Authors:  S Lin; J A Spudich
Journal:  Biochem Biophys Res Commun       Date:  1974-12-23       Impact factor: 3.575

9.  Cytochalasin B: lack of effect on mucopolysaccharide synthesis and selective alterations in precursor uptake.

Authors:  R H Cohn; S D Banerjee; E R Shelton; M R Bernfield
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

10.  Cytochalasin B: inhibition of glucose and glucosamine transport.

Authors:  R D Ebstensen; P G Plagemann
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205
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