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Literature DB >> 11060595

Calcium channel blockers and pain therapy.

Abstract

This review focuses on the advances in the development of N-type calcium channel blockers as analgesic agents over the last 2 years. Firstly, it highlights the clinical progress with SNX-111 (Ziconotide; Elan Pharmaceuticals, Smithfield, RI) and then secondly, it outlines the various approaches being taken by researchers to design orally active, selective, small molecule modulators without the perceived disadvantages associated with SNX-111.

Entities: Disease

Mesh：

Substances：
Calcium Channel Blockers

Year: 2000 PMID： 11060595 DOI： 10.1007/s11916-000-0073-8

Source DB: PubMed Journal: Curr Rev Pain ISSN： 1069-5850

22 in total

1. Multiple parallel synthesis of N,N-dialkyldipeptidylamines as N-type calcium channel blockers.

Authors: T R Ryder; L Y Hu; M F Rafferty; E Millerman; B G Szoke; K Tarczy-Hornoch
Journal: Bioorg Med Chem Lett Date: 1999-07-05 Impact factor: 2.823

Review 2. Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels.

Authors: K J Nielsen; T Schroeder; R Lewis
Journal: J Mol Recognit Date: 2000 Mar-Apr Impact factor: 2.137

3. N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.

Authors: L Y Hu; T R Ryder; M F Rafferty; W L Cody; S M Lotarski; G P Miljanich; E Millerman; D M Rock; Y Song; S J Stoehr; C P Taylor; M L Weber; B G Szoke; M G Vartanian
Journal: Bioorg Med Chem Lett Date: 1999-03-22 Impact factor: 2.823

4. The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia.

Authors: L Y Hu; T R Ryder; M F Rafferty; C P Taylor; M R Feng; B S Kuo; S M Lotarski; G P Miljanich; E Millerman; K M Siebers; B G Szoke
Journal: Bioorg Med Chem Date: 2000-06 Impact factor: 3.641

5. Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain.

Authors: P G Atanassoff; M W Hartmannsgruber; J Thrasher; D Wermeling; W Longton; R Gaeta; T Singh; M Mayo; D McGuire; R R Luther
Journal: Reg Anesth Pain Med Date: 2000 May-Jun Impact factor: 6.288

6. Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain.

Authors: Z Lin; S Haus; J Edgerton; D Lipscombe
Journal: Neuron Date: 1997-01 Impact factor: 17.173

7. Roles of key functional groups in omega-conotoxin GVIA synthesis, structure and functional assay of selected peptide analogues.

Authors: J P Flinn; P K Pallaghy; M J Lew; R Murphy; J A Angus; R S Norton
Journal: Eur J Biochem Date: 1999-06

8. Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells.

Authors: F Deák; B Lasztóczi; P Pacher; G L Petheö; A Spät
Journal: Neuropharmacology Date: 2000-04-03 Impact factor: 5.250

9. Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.

Authors: L Y Hu; T R Ryder; M F Rafferty; M R Feng; S M Lotarski; D M Rock; M Sinz; S J Stoehr; C P Taylor; M L Weber; S S Bowersox; G P Miljanich; E Millerman; Y X Wang; B G Szoke
Journal: J Med Chem Date: 1999-10-07 Impact factor: 7.446

10. Fluspirilene block of N-type calcium current in NGF-differentiated PC12 cells.

Authors: C J Grantham; M J Main; M B Cannell
Journal: Br J Pharmacol Date: 1994-02 Impact factor: 8.739

5 in total

1. Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn.

Authors: Beth K Rycroft; Kristina S Vikman; MacDonald J Christie
Journal: J Physiol Date: 2007-02-15 Impact factor: 5.182