| Literature DB >> 10206559 |
L Y Hu1, T R Ryder, M F Rafferty, W L Cody, S M Lotarski, G P Miljanich, E Millerman, D M Rock, Y Song, S J Stoehr, C P Taylor, M L Weber, B G Szoke, M G Vartanian.
Abstract
Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown utility in several models of stroke and pain. We are especially interested in small molecule N-type calcium channel blockers for therapeutic use. Herein, we report a series of N,N-dialkyl-dipeptidylamines with potent functional activity at N-type VSCCs and in vivo efficacy. The synthesis, SAR, and pharmacological evaluation of this series are discussed.Entities:
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Year: 1999 PMID： 10206559 DOI： 10.1016/s0960-894x(99)00100-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823