| Literature DB >> 10406647 |
T R Ryder1, L Y Hu, M F Rafferty, E Millerman, B G Szoke, K Tarczy-Hornoch.
Abstract
Selective N-type Voltage Sensitive Calcium Channel (VSCC) blockers have shown utility in several models of stroke and pain. A series of N,N-dialkyldipeptidylamines with potent functional activity at N-type VSCC's has been identified. Multiple parallel synthesis of a focused array of thirty compounds using polymer-supported quenching reagents and preliminary pharmacology are presented. Eighteen compounds were identified with an IC50 below 1 microM in an in vitro functional assay.Entities:
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Year: 1999 PMID： 10406647 DOI： 10.1016/s0960-894x(99)00284-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823