Literature DB >> 11055366

Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values.

P C Sham1, J H Zhao, S S Cherny, J K Hewitt.   

Abstract

Standard variance-components quantitative trait loci (QTL) linkage analysis can produce an elevated rate of type 1 errors when applied to selected samples and non-normal data. Here we describe an adjustment of the log-likelihood function based on conditioning on trait values. This leads to a likelihood ratio test that is valid in selected samples and non-normal data, and equal in power to alternative methods for analyzing selected samples that require knowledge of the ascertainment procedure or the trait values of non-selected individuals.

Mesh：

Year:  2000        PMID： 11055366     DOI： 10.1002/1098-2272(2000)19:1+<::AID-GEPI4>3.0.CO;2-S

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  12 in total

1.  A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size.

Authors:  K Wang; J Huang
Journal:  Am J Hum Genet       Date:  2001-12-27       Impact factor: 11.025

2.  A genomewide linkage scan for quantitative-trait loci for obesity phenotypes.

Authors:  Hong-Wen Deng; Hongyi Deng; Yong-Jun Liu; Yao-Zhong Liu; Fu-Hua Xu; Hui Shen; Theresa Conway; Jin-Long Li; Qing-Yang Huang; K M Davies; Robert R Recker
Journal:  Am J Hum Genet       Date:  2002-03-28       Impact factor: 11.025

3.  Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs.

Authors:  P C Sham; S Purcell
Journal:  Am J Hum Genet       Date:  2001-05-14       Impact factor: 11.025

4.  Powerful regression-based quantitative-trait linkage analysis of general pedigrees.

Authors:  Pak C Sham; Shaun Purcell; Stacey S Cherny; Gonçalo R Abecasis
Journal:  Am J Hum Genet       Date:  2002-07-05       Impact factor: 11.025

5.  Theoretical and empirical power of regression and maximum-likelihood methods to map quantitative trait loci in general pedigrees.

Authors:  Xijiang Yu; Sara A Knott; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2004-05-19       Impact factor: 11.025

6.  Robust score statistics for QTL linkage analysis.

Authors:  Samsiddhi Bhattacharjee; Chia-Ling Kuo; Nandita Mukhopadhyay; Guy N Brock; Daniel E Weeks; Eleanor Feingold
Journal:  Am J Hum Genet       Date:  2008-02-21       Impact factor: 11.025

7.  Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.

Authors:  Steven Wiltshire; Timothy M Frayling; Andrew T Hattersley; Graham A Hitman; Mark Walker; Jonathan C Levy; Stephen O'Rahilly; Christopher J Groves; Stephan Menzel; Lon R Cardon; Mark I McCarthy
Journal:  Am J Hum Genet       Date:  2001-12-20       Impact factor: 11.025

8.  Mixed effects models for quantitative trait loci mapping with inbred strains.

Authors:  Lara E Bauman; Janet S Sinsheimer; Eric M Sobel; Kenneth Lange
Journal:  Genetics       Date:  2008-09-14       Impact factor: 4.562

9.  Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.

Authors:  Benjamin M Neale; Sarah E Medland; Stephan Ripke; Philip Asherson; Barbara Franke; Klaus-Peter Lesch; Stephen V Faraone; Thuy Trang Nguyen; Helmut Schäfer; Peter Holmans; Mark Daly; Hans-Christoph Steinhausen; Christine Freitag; Andreas Reif; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Susanne Walitza; Andreas Warnke; Jobst Meyer; Haukur Palmason; Jan Buitelaar; Alejandro Arias Vasquez; Nanda Lambregts-Rommelse; Michael Gill; Richard J L Anney; Kate Langely; Michael O'Donovan; Nigel Williams; Michael Owen; Anita Thapar; Lindsey Kent; Joseph Sergeant; Herbert Roeyers; Eric Mick; Joseph Biederman; Alysa Doyle; Susan Smalley; Sandra Loo; Hakon Hakonarson; Josephine Elia; Alexandre Todorov; Ana Miranda; Fernando Mulas; Richard P Ebstein; Aribert Rothenberger; Tobias Banaschewski; Robert D Oades; Edmund Sonuga-Barke; James McGough; Laura Nisenbaum; Frank Middleton; Xiaolan Hu; Stan Nelson
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2010-08-01       Impact factor: 8.829

10.  Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs.

Authors:  Jin P Szatkiewicz; Karen T Cuenco; Eleanor Feingold
Journal:  Am J Hum Genet       Date:  2003-09-10       Impact factor: 11.025
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