Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.

Literature DB >> 11753821

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.

Steven Wiltshire¹, Timothy M Frayling, Andrew T Hattersley, Graham A Hitman, Mark Walker, Jonathan C Levy, Stephen O'Rahilly, Christopher J Groves, Stephan Menzel, Lon R Cardon, Mark I McCarthy.

Abstract

We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM. We found evidence for a locus on 3p26 (LOD score 3.17) influencing height in this adult sample, with less-significant evidence for loci on chromosomes 7, 10, 15, 17, 19, and 20. Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes.

Entities: Disease Gene

Mesh：

Year: 2001 PMID： 11753821 PMCID： PMC384928 DOI： 10.1086/338760

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

15 in total

1. DeFries-Fulker multiple regression analysis of sibship QTL data: a SAS macro.

Authors: J M Lessem; S S Cherny; J L Lessem
Journal: Bioinformatics Date: 2001-04 Impact factor: 6.937

2. Initial sequencing and analysis of the human genome.

Authors: E S Lander; L M Linton; B Birren; C Nusbaum; M C Zody; J Baldwin; K Devon; K Dewar; M Doyle; W FitzHugh; R Funke; D Gage; K Harris; A Heaford; J Howland; L Kann; J Lehoczky; R LeVine; P McEwan; K McKernan; J Meldrim; J P Mesirov; C Miranda; W Morris; J Naylor; C Raymond; M Rosetti; R Santos; A Sheridan; C Sougnez; Y Stange-Thomann; N Stojanovic; A Subramanian; D Wyman; J Rogers; J Sulston; R Ainscough; S Beck; D Bentley; J Burton; C Clee; N Carter; A Coulson; R Deadman; P Deloukas; A Dunham; I Dunham; R Durbin; L French; D Grafham; S Gregory; T Hubbard; S Humphray; A Hunt; M Jones; C Lloyd; A McMurray; L Matthews; S Mercer; S Milne; J C Mullikin; A Mungall; R Plumb; M Ross; R Shownkeen; S Sims; R H Waterston; R K Wilson; L W Hillier; J D McPherson; M A Marra; E R Mardis; L A Fulton; A T Chinwalla; K H Pepin; W R Gish; S L Chissoe; M C Wendl; K D Delehaunty; T L Miner; A Delehaunty; J B Kramer; L L Cook; R S Fulton; D L Johnson; P J Minx; S W Clifton; T Hawkins; E Branscomb; P Predki; P Richardson; S Wenning; T Slezak; N Doggett; J F Cheng; A Olsen; S Lucas; C Elkin; E Uberbacher; M Frazier; R A Gibbs; D M Muzny; S E Scherer; J B Bouck; E J Sodergren; K C Worley; C M Rives; J H Gorrell; M L Metzker; S L Naylor; R S Kucherlapati; D L Nelson; G M Weinstock; Y Sakaki; A Fujiyama; M Hattori; T Yada; A Toyoda; T Itoh; C Kawagoe; H Watanabe; Y Totoki; T Taylor; J Weissenbach; R Heilig; W Saurin; F Artiguenave; P Brottier; T Bruls; E Pelletier; C Robert; P Wincker; D R Smith; L Doucette-Stamm; M Rubenfield; K Weinstock; H M Lee; J Dubois; A Rosenthal; M Platzer; G Nyakatura; S Taudien; A Rump; H Yang; J Yu; J Wang; G Huang; J Gu; L Hood; L Rowen; A Madan; S Qin; R W Davis; N A Federspiel; A P Abola; M J Proctor; R M Myers; J Schmutz; M Dickson; J Grimwood; D R Cox; M V Olson; R Kaul; C Raymond; N Shimizu; K Kawasaki; S Minoshima; G A Evans; M Athanasiou; R Schultz; B A Roe; F Chen; H Pan; J Ramser; H Lehrach; R Reinhardt; W R McCombie; M de la Bastide; N Dedhia; H Blöcker; K Hornischer; G Nordsiek; R Agarwala; L Aravind; J A Bailey; A Bateman; S Batzoglou; E Birney; P Bork; D G Brown; C B Burge; L Cerutti; H C Chen; D Church; M Clamp; R R Copley; T Doerks; S R Eddy; E E Eichler; T S Furey; J Galagan; J G Gilbert; C Harmon; Y Hayashizaki; D Haussler; H Hermjakob; K Hokamp; W Jang; L S Johnson; T A Jones; S Kasif; A Kaspryzk; S Kennedy; W J Kent; P Kitts; E V Koonin; I Korf; D Kulp; D Lancet; T M Lowe; A McLysaght; T Mikkelsen; J V Moran; N Mulder; V J Pollara; C P Ponting; G Schuler; J Schultz; G Slater; A F Smit; E Stupka; J Szustakowki; D Thierry-Mieg; J Thierry-Mieg; L Wagner; J Wallis; R Wheeler; A Williams; Y I Wolf; K H Wolfe; S P Yang; R F Yeh; F Collins; M S Guyer; J Peterson; A Felsenfeld; K A Wetterstrand; A Patrinos; M J Morgan; P de Jong; J J Catanese; K Osoegawa; H Shizuya; S Choi; Y J Chen; J Szustakowki
Journal: Nature Date: 2001-02-15 Impact factor: 49.962

3. Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values.

Authors: P C Sham; J H Zhao; S S Cherny; J K Hewitt
Journal: Genet Epidemiol Date: 2000 Impact factor: 2.135

4. Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups.

Authors: M Perola; M Ohman; T Hiekkalinna; J Leppävuori; P Pajukanta; M Wessman; M Koskenvuo; A Palotie; K Lange; J Kaprio; L Peltonen
Journal: Am J Hum Genet Date: 2001-06-15 Impact factor: 11.025

5. Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height.

Authors: J N Hirschhorn; C M Lindgren; M J Daly; A Kirby; S F Schaffner; N P Burtt; D Altshuler; A Parker; J D Rioux; J Platko; D Gaudet; T J Hudson; L C Groop; E S Lander
Journal: Am J Hum Genet Date: 2001-06-15 Impact factor: 11.025

6. Large upward bias in estimation of locus-specific effects from genomewide scans.

Authors: H H Göring; J D Terwilliger; J Blangero
Journal: Am J Hum Genet Date: 2001-10-09 Impact factor: 11.025

7. Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs.

Authors: P C Sham; S Purcell
Journal: Am J Hum Genet Date: 2001-05-14 Impact factor: 11.025

8. A comprehensive genetic map of the human genome based on 5,264 microsatellites.

Authors: C Dib; S Fauré; C Fizames; D Samson; N Drouot; A Vignal; P Millasseau; S Marc; J Hazan; E Seboun; M Lathrop; G Gyapay; J Morissette; J Weissenbach
Journal: Nature Date: 1996-03-14 Impact factor: 49.962

9. The investigation of linkage between a quantitative trait and a marker locus.

Authors: J K Haseman; R C Elston
Journal: Behav Genet Date: 1972-03 Impact factor: 2.805

10. A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

Authors: S Wiltshire; A T Hattersley; G A Hitman; M Walker; J C Levy; M Sampson; S O'Rahilly; T M Frayling; J I Bell; G M Lathrop; A Bennett; R Dhillon; C Fletcher; C J Groves; E Jones; P Prestwich; N Simecek; P V Rao; M Wishart; G F Bottazzo; R Foxon; S Howell; D Smedley; L R Cardon; S Menzel; M I McCarthy
Journal: Am J Hum Genet Date: 2001-08-01 Impact factor: 11.025

20 in total

1. Use of multivariate linkage analysis for dissection of a complex cognitive trait.

Authors: Angela J Marlow; Simon E Fisher; Clyde Francks; I Laurence MacPhie; Stacey S Cherny; Alex J Richardson; Joel B Talcott; John F Stein; Anthony P Monaco; Lon R Cardon
Journal: Am J Hum Genet Date: 2003-02-13 Impact factor: 11.025

2. Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.

Authors: Jianfeng Xu; Eugene R Bleecker; Hajo Jongepier; Timothy D Howard; Gerard H Koppelman; Dirkje S Postma; Deborah A Meyers
Journal: Am J Hum Genet Date: 2002-07-15 Impact factor: 11.025

3. A male-specific quantitative trait locus on 1p21 controlling human stature.

Authors: S Sammalisto; T Hiekkalinna; E Suviolahti; K Sood; A Metzidis; P Pajukanta; H E Lilja; A Soro-Paavonen; M-R Taskinen; T Tuomi; P Almgren; M Orho-Melander; L Groop; L Peltonen; M Perola
Journal: J Med Genet Date: 2005-04-12 Impact factor: 6.318

4. Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population.

Authors: Justine A Ellis; Katrina J Scurrah; Anna E Duncan; Angela Lamantia; Graham B Byrnes; Stephen B Harrap
Journal: Hum Genet Date: 2006-12-20 Impact factor: 4.132

5. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia.

Authors: Dvora Shmulewitz; Simon C Heath; Maude L Blundell; Zhihua Han; Ratnendra Sharma; Jacqueline Salit; Steven B Auerbach; Stefano Signorini; Jan L Breslow; Markus Stoffel; Jeffrey M Friedman
Journal: Proc Natl Acad Sci U S A Date: 2006-02-28 Impact factor: 11.205

6. Genome partitioning of genetic variation for height from 11,214 sibling pairs.

Authors: Peter M Visscher; Stuart Macgregor; Beben Benyamin; Gu Zhu; Scott Gordon; Sarah Medland; William G Hill; Jouke-Jan Hottenga; Gonneke Willemsen; Dorret I Boomsma; Yao-Zhong Liu; Hong-Wen Deng; Grant W Montgomery; Nicholas G Martin
Journal: Am J Hum Genet Date: 2007-10-01 Impact factor: 11.025

7. Vitamin D receptor gene polymorphisms are linked to and associated with adult height.

Authors: D-H Xiong; F-H Xu; P-Y Liu; H Shen; J-R Long; L Elze; R R Recker; H-W Deng
Journal: J Med Genet Date: 2005-03 Impact factor: 6.318

8. Transferability and fine-mapping of genome-wide associated loci for adult height across human populations.

Authors: Daniel Shriner; Adebowale Adeyemo; Norman P Gerry; Alan Herbert; Guanjie Chen; Ayo Doumatey; Hanxia Huang; Jie Zhou; Michael F Christman; Charles N Rotimi
Journal: PLoS One Date: 2009-12-22 Impact factor: 3.240

9. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.

Authors: Shu-Feng Lei; Tie-Lin Yang; Li-Jun Tan; Xiang-Ding Chen; Yan Guo; Yan-Fang Guo; Liang Zhang; Xiao-Gang Liu; Han Yan; Feng Pan; Zhi-Xin Zhang; Yu-Mei Peng; Qi Zhou; Li-Na He; Xue-Zhen Zhu; Jing Cheng; Yao-Zhong Liu; Christopher J Papasian; Hong-Wen Deng
Journal: Hum Genet Date: 2008-11-23 Impact factor: 4.132

10. Multivariate association test using haplotype trend regression.

Authors: Yu-Fang Pei; Lei Zhang; Jianfeng Liu; Hong-Wen Deng
Journal: Ann Hum Genet Date: 2009-06-01 Impact factor: 1.670