| Literature DB >> 11032031 |
H Poirel1, R G Lopez, V Lacronique, V Della Valle, M Mauchauffé, R Berger, J Ghysdael, O A Bernard.
Abstract
The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.Entities:
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Year: 2000 PMID： 11032031 DOI： 10.1038/sj.onc.1203830
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867