Literature DB >> 11483520

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression.

C A Kim1, M L Phillips, W Kim, M Gingery, H H Tran, M A Robinson, S Faham, J U Bowie.   

Abstract

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

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Year:  2001        PMID： 11483520      PMCID： PMC149168          DOI： 10.1093/emboj/20.15.4173

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  52 in total

1.  Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

Authors:  S W Chi; A Ayed; C H Arrowsmith
Journal:  EMBO J       Date:  1999-08-16       Impact factor: 11.598

2.  DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition.

Authors:  B R Szymczyna; C H Arrowsmith
Journal:  J Biol Chem       Date:  2000-09-15       Impact factor: 5.157

3.  Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites.

Authors:  M Smalla; P Schmieder; M Kelly; A Ter Laak; G Krause; L Ball; M Wahl; P Bork; H Oschkinat
Journal:  Protein Sci       Date:  1999-10       Impact factor: 6.725

4.  A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions.

Authors:  A J Peterson; M Kyba; D Bornemann; K Morgan; H W Brock; J Simon
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

Review 5.  Polycombing the genome: PcG, trxG, and chromatin silencing.

Authors:  V Pirrotta
Journal:  Cell       Date:  1998-05-01       Impact factor: 41.582

6.  Crystal structure of the nucleosome core particle at 2.8 A resolution.

Authors:  K Luger; A W Mäder; R K Richmond; D F Sargent; T J Richmond
Journal:  Nature       Date:  1997-09-18       Impact factor: 49.962

7.  TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.

Authors:  R Fenrick; L Wang; J Nip; J M Amann; R J Rooney; J Walker-Daniels; H C Crawford; D L Hulboy; M S Kinch; L M Matrisian; S W Hiebert
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

8.  Automated MAD and MIR structure solution.

Authors:  T C Terwilliger; J Berendzen
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-04

9.  Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.

Authors:  G D Van Duyne; R F Standaert; P A Karplus; S L Schreiber; J Clardy
Journal:  J Mol Biol       Date:  1993-01-05       Impact factor: 5.469

10.  The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

Authors:  S P Romana; M Mauchauffé; M Le Coniat; I Chumakov; D Le Paslier; R Berger; O A Bernard
Journal:  Blood       Date:  1995-06-15       Impact factor: 22.113
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  90 in total

1.  Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.

Authors:  Mary L Nelson; Hyun-Seo Kang; Gregory M Lee; Adam G Blaszczak; Desmond K W Lau; Lawrence P McIntosh; Barbara J Graves
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-13       Impact factor: 11.205

2.  Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors.

Authors:  Cameron D Mackereth; Manuela Schärpf; Lisa N Gentile; Lawrence P McIntosh
Journal:  J Biomol NMR       Date:  2002-09       Impact factor: 2.835

3.  Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation.

Authors:  Kazuhiro Maki; Honoka Arai; Kazuo Waga; Ko Sasaki; Fumihiko Nakamura; Yoichi Imai; Mineo Kurokawa; Hisamaru Hirai; Kinuko Mitani
Journal:  Mol Cell Biol       Date:  2004-04       Impact factor: 4.272

Review 4.  Dual-function transcription factors and their entourage: unique and unifying themes governing two pathogenesis-related genes.

Authors:  Patrick Boyle; Charles Després
Journal:  Plant Signal Behav       Date:  2010-06-01

5.  Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.

Authors:  Angela K Robinson; Belinda Z Leal; David R Nanyes; Yogeet Kaur; Udayar Ilangovan; Virgil Schirf; Andrew P Hinck; Borries Demeler; Chongwoo A Kim
Journal:  Biochemistry       Date:  2012-06-28       Impact factor: 3.162

Review 6.  ETV6 in hematopoiesis and leukemia predisposition.

Authors:  Hanno Hock; Akiko Shimamura
Journal:  Semin Hematol       Date:  2017-04-07       Impact factor: 3.851

7.  The growth-suppressive function of the polycomb group protein polyhomeotic is mediated by polymerization of its sterile alpha motif (SAM) domain.

Authors:  Angela K Robinson; Belinda Z Leal; Linda V Chadwell; Renjing Wang; Udayar Ilangovan; Yogeet Kaur; Sarah E Junco; Virgil Schirf; Pawel A Osmulski; Maria Gaczynska; Andrew P Hinck; Borries Demeler; Donald G McEwen; Chongwoo A Kim
Journal:  J Biol Chem       Date:  2012-01-24       Impact factor: 5.157

8.  TEL/ETV6 binds to corepressor KAP1 via the HLH domain.

Authors:  Yuka Nakamura; Tetsuya Yamagata; Kazuhiro Maki; Ko Sasaki; Issay Kitabayashi; Kinuko Mitani
Journal:  Int J Hematol       Date:  2006-11       Impact factor: 2.490

9.  CBFbeta is critical for AML1-ETO and TEL-AML1 activity.

Authors:  Liya Roudaia; Matthew D Cheney; Ekaterina Manuylova; Wei Chen; Michelle Morrow; Sangho Park; Chung-Tsai Lee; Prabhjot Kaur; Owen Williams; John H Bushweller; Nancy A Speck
Journal:  Blood       Date:  2009-01-29       Impact factor: 22.113

10.  NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor.

Authors:  Marilisa Leone; Jason Cellitti; Maurizio Pellecchia
Journal:  Biochemistry       Date:  2008-12-02       Impact factor: 3.162
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