Literature DB >> 11016962

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice.

J Marks-Konczalik1, S Dubois, J M Losi, H Sabzevari, N Yamada, L Feigenbaum, T A Waldmann, Y Tagaya.   

Abstract

A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44(hi)CD8 memory T cells, and gammadelta T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8alphaalpha' expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.

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Year:  2000        PMID： 11016962      PMCID： PMC17219          DOI： 10.1073/pnas.200363097

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

Authors:  R N Bamford; A P Battiata; J D Burton; H Sharma; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-02       Impact factor: 11.205

Review 2.  IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels.

Authors:  Y Tagaya; R N Bamford; A P DeFilippis; T A Waldmann
Journal:  Immunity       Date:  1996-04       Impact factor: 31.745

3.  The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Authors:  R N Bamford; A J Grant; J D Burton; C Peters; G Kurys; C K Goldman; J Brennan; E Roessler; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

4.  Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.

Authors:  K H Grabstein; J Eisenman; K Shanebeck; C Rauch; S Srinivasan; V Fung; C Beers; J Richardson; M A Schoenborn; M Ahdieh
Journal:  Science       Date:  1994-05-13       Impact factor: 47.728

5.  IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.

Authors:  J P Lodolce; D L Boone; S Chai; R E Swain; T Dassopoulos; S Trettin; A Ma
Journal:  Immunity       Date:  1998-11       Impact factor: 31.745

6.  IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

Authors:  H Nishimura; K Hiromatsu; N Kobayashi; K H Grabstein; R Paxton; K Sugamura; J A Bluestone; Y Yoshikai
Journal:  J Immunol       Date:  1996-01-15       Impact factor: 5.422

7.  Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.

Authors:  D M Willerford; J Chen; J A Ferry; L Davidson; A Ma; F W Alt
Journal:  Immunity       Date:  1995-10       Impact factor: 31.745

8.  Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptor.

Authors:  D Edelbaum; M Mohamadzadeh; P R Bergstresser; K Sugamura; A Takashima
Journal:  J Invest Dermatol       Date:  1995-12       Impact factor: 8.551

9.  Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

Authors:  J G Giri; S Kumaki; M Ahdieh; D J Friend; A Loomis; K Shanebeck; R DuBose; D Cosman; L S Park; D M Anderson
Journal:  EMBO J       Date:  1995-08-01       Impact factor: 11.598

10.  Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

Authors:  W E Carson; J G Giri; M J Lindemann; M L Linett; M Ahdieh; R Paxton; D Anderson; J Eisenmann; K Grabstein; M A Caligiuri
Journal:  J Exp Med       Date:  1994-10-01       Impact factor: 14.307
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  140 in total

1.  IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

Authors:  N Azimi; M Nagai; S Jacobson; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

Review 2.  Qualitative differences between naïve and memory T cells.

Authors:  Marion Berard; David F Tough
Journal:  Immunology       Date:  2002-06       Impact factor: 7.397

3.  Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.

Authors:  SangKon Oh; Jay A Berzofsky; Donald S Burke; Thomas A Waldmann; Liyanage P Perera
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

4.  Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.

Authors:  P Matthys; H Dooms; P Rottiers; T Mitera; L Overgergh; G Leclercq; A Billiau; J Grooten
Journal:  Clin Exp Immunol       Date:  2002-12       Impact factor: 4.330

Review 5.  Concise review: engineering the fusion of cytokines for the modulation of immune cellular responses in cancer and autoimmune disorders.

Authors:  Spencer Ng; Jacques Galipeau
Journal:  Stem Cells Transl Med       Date:  2014-11-12       Impact factor: 6.940

6.  Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.

Authors:  Meili Zhang; Wei Ju; Zhengsheng Yao; Ping Yu; Bih-Rong Wei; R Mark Simpson; Rebecca Waitz; Marcella Fassò; James P Allison; Thomas A Waldmann
Journal:  J Immunol       Date:  2012-05-16       Impact factor: 5.422

Review 7.  The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.

Authors:  Pin-Yu Perera; Jack H Lichy; Thomas A Waldmann; Liyanage P Perera
Journal:  Microbes Infect       Date:  2011-10-25       Impact factor: 2.700

8.  Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells.

Authors:  Minchan Gil; Seo-Jeong Park; Yoo-Sam Chung; Chan-Sik Park
Journal:  Immunology       Date:  2010-03-16       Impact factor: 7.397

9.  IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity.

Authors:  Rajia Bahri; Ioannis S Pateras; Orietta D'Orlando; Diego A Goyeneche-Patino; Michelle Campbell; Julia K Polansky; Hilary Sandig; Marilena Papaioannou; Kostas Evangelou; Periklis G Foukas; Vassilis G Gorgoulis; Silvia Bulfone-Paus
Journal:  Oncoimmunology       Date:  2015-01-22       Impact factor: 8.110

10.  IL-15 Agonists: The Cancer Cure Cytokine.

Authors:  Jennifer Wu
Journal:  J Mol Genet Med       Date:  2013-10-28
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