Literature DB >> 22064066

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.

Pin-Yu Perera1, Jack H Lichy, Thomas A Waldmann, Liyanage P Perera.   

Abstract

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infectious pathogens. Published by Elsevier Masson SAS.

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Year:  2011        PMID： 22064066      PMCID： PMC3270128          DOI： 10.1016/j.micinf.2011.10.006

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  137 in total

1.  Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-alpha) receptors in type C chronic liver disease.

Authors:  S Kakumu; A Okumura; T Ishikawa; M Yano; A Enomoto; H Nishimura; K Yoshioka; Y Yoshika
Journal:  Clin Exp Immunol       Date:  1997-09       Impact factor: 4.330

Review 2.  Adjuvant activity of cytokines.

Authors:  Michael G Tovey; Christophe Lallemand
Journal:  Methods Mol Biol       Date:  2010

3.  Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.

Authors:  H Dooms; M Desmedt; S Vancaeneghem; P Rottiers; V Goossens; W Fiers; J Grooten
Journal:  J Immunol       Date:  1998-09-01       Impact factor: 5.422

4.  IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

Authors:  Shigeaki Inoue; Jacqueline Unsinger; Christopher G Davis; Jared T Muenzer; Thomas A Ferguson; Katherine Chang; Dale F Osborne; Andrew T Clark; Craig M Coopersmith; Jonathan E McDunn; Richard S Hotchkiss
Journal:  J Immunol       Date:  2009-12-21       Impact factor: 5.422

5.  Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice.

Authors:  Vanja Lazarevic; David J Yankura; Sherrie J DiVito; JoAnne L Flynn
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

6.  Safety and immunologic effects of IL-15 administration in nonhuman primates.

Authors:  Carolina Berger; Michael Berger; Robert C Hackman; Michael Gough; Carole Elliott; Michael C Jensen; Stanley R Riddell
Journal:  Blood       Date:  2009-07-15       Impact factor: 22.113

7.  Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

Authors:  X Zhang; S Sun; I Hwang; D F Tough; J Sprent
Journal:  Immunity       Date:  1998-05       Impact factor: 31.745

8.  Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties.

Authors:  Sébastien Anguille; Evelien L J M Smits; Nathalie Cools; Herman Goossens; Zwi N Berneman; Vigor F I Van Tendeloo
Journal:  J Transl Med       Date:  2009-12-18       Impact factor: 5.531

9.  Intracellular IL-15 controls mast cell survival.

Authors:  Farhad Mirghomizadeh; Supandi Winoto-Morbach; Zane Orinska; Kyeong-Hee Lee; Stefan Schütze; Silvia Bulfone-Paus
Journal:  Exp Cell Res       Date:  2009-07-23       Impact factor: 3.905

10.  The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells.

Authors:  T Ohteki; H Yoshida; T Matsuyama; G S Duncan; T W Mak; P S Ohashi
Journal:  J Exp Med       Date:  1998-03-16       Impact factor: 14.307
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  61 in total

1.  IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.

Authors:  Yin Guo; Liming Luan; Whitney Rabacal; Julia K Bohannon; Benjamin A Fensterheim; Antonio Hernandez; Edward R Sherwood
Journal:  J Immunol       Date:  2015-07-27       Impact factor: 5.422

2.  CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans.

Authors:  Adam T Waickman; Davinna L Ligons; SuJin Hwang; Joo-Young Park; Vanja Lazarevic; Noriko Sato; Changwan Hong; Jung-Hyun Park
Journal:  Cytokine       Date:  2017-08-12       Impact factor: 3.861

3.  Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated With Cell-Mediated and Humoral Immunity.

Authors:  Abhishek N Prasad; Courtney Woolsey; Joan B Geisbert; Krystle N Agans; Viktoriya Borisevich; Daniel J Deer; Chad E Mire; Robert W Cross; Karla A Fenton; Christopher C Broder; Thomas W Geisbert
Journal:  J Infect Dis       Date:  2020-05-11       Impact factor: 5.226

4.  Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo.

Authors:  Yanqun Wang; Jing Sun; Xiaobo Li; Airu Zhu; Wenda Guan; De-Qiang Sun; Jingxian Zhao; Jicheng Huang; Jincun Zhao; Mian Gan; Xuefeng Niu; Jun Dai; Lu Zhang; Zhaoyong Zhang; Yongxia Shi; Shuxiang Huang; Chris Ka Pun Mok; Zifeng Yang; Zhongfang Wang; Wenjie Tan; Yimin Li; Ling Chen; Rongchang Chen; Malik Peiris; Nanshan Zhong
Journal:  J Virol       Date:  2020-07-16       Impact factor: 5.103

5.  T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum.

Authors:  E Antiga; R Maglie; W Volpi; B Bianchi; E Berti; A V Marzano; M Caproni
Journal:  Clin Exp Immunol       Date:  2017-06-23       Impact factor: 4.330

6.  Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice.

Authors:  Tiange Chen; Yajing Zhang; Zhao Wang; Jie Yang; Mingming Li; Kunlun Wang; Min Cui; Zhen F Fu; Ling Zhao; Ming Zhou
Journal:  Virol Sin       Date:  2017-08-29       Impact factor: 4.327

7.  Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses.

Authors:  Sapna Patel; Archana Akalkotkar; Joseph J Bivona; Ji-Young Lee; Young-Ki Park; Mingke Yu; Sara L Colpitts; Michael Vajdy
Journal:  Immunology       Date:  2016-06-22       Impact factor: 7.397

8.  Impact of brief exercise on peripheral blood NK cell gene and microRNA expression in young adults.

Authors:  Shlomit Radom-Aizik; Frank Zaldivar; Fadia Haddad; Dan M Cooper
Journal:  J Appl Physiol (1985)       Date:  2013-01-03

9.  Lipopolysaccharide-Induced Profiles of Cytokine, Chemokine, and Growth Factors Produced by Human Decidual Cells Are Altered by Lactobacillus rhamnosus GR-1 Supernatant.

Authors:  Wei Li; Siwen Yang; Sung O Kim; Gregor Reid; John R G Challis; Alan D Bocking
Journal:  Reprod Sci       Date:  2014-01-15       Impact factor: 3.060

10.  Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.

Authors:  Kartik Sehgal; Ragy Ragheb; Tarek M Fahmy; Madhav V Dhodapkar; Kavita M Dhodapkar
Journal:  J Immunol       Date:  2014-07-30       Impact factor: 5.422
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