BACKGROUND AND PURPOSE: MR imaging findings of cerebellar cortical dysplasia have been described as a new cerebellar malformation. The purpose of this study was to assess the association of cerebellar cortical dysplasia with other cerebral malformations. METHODS: We retrospectively reviewed 46 MR examinations of patients presenting with developmental delay, hypotonia, and facial deformities to identify abnormal folia or fissures or both within cerebellar hemispheres or vermis suggesting cortical dysplasia. RESULTS: Cerebellar cortical dysplasia was diagnosed in 17 patients. In two patients, it was isolated. In the remaining 15 patients, the malformation was associated with vermian malformation (n=11), cerebral cortical dysplasias (n=8), dysplasia of corpus callosum (n=6), and heterotopia (n=5). A widespread malformation of the posterior fossa was observed in eight patients (Dandy-Walker, Chiari II and III, and hypoplasia of brain stem). One patient with hypertrophied cerebellar hemisphere had minor enlargement of the right cerebral hemisphere and lateral ventricle. He also had nodular heterotopia, suggesting unilateral megalencephaly. CONCLUSION: Our study suggests that cerebellar cortical dysplasias are common in cases with more widespread cerebral malformations. Technical progress providing high-quality tridimensional MR imaging of the cerebellum may explain its recent descriptions.
BACKGROUND AND PURPOSE: MR imaging findings of cerebellar cortical dysplasia have been described as a new cerebellar malformation. The purpose of this study was to assess the association of cerebellar cortical dysplasia with other cerebral malformations. METHODS: We retrospectively reviewed 46 MR examinations of patients presenting with developmental delay, hypotonia, and facial deformities to identify abnormal folia or fissures or both within cerebellar hemispheres or vermis suggesting cortical dysplasia. RESULTS:Cerebellar cortical dysplasia was diagnosed in 17 patients. In two patients, it was isolated. In the remaining 15 patients, the malformation was associated with vermian malformation (n=11), cerebral cortical dysplasias (n=8), dysplasia of corpus callosum (n=6), and heterotopia (n=5). A widespread malformation of the posterior fossa was observed in eight patients (Dandy-Walker, Chiari II and III, and hypoplasia of brain stem). One patient with hypertrophied cerebellar hemisphere had minor enlargement of the right cerebral hemisphere and lateral ventricle. He also had nodular heterotopia, suggesting unilateral megalencephaly. CONCLUSION: Our study suggests that cerebellar cortical dysplasias are common in cases with more widespread cerebral malformations. Technical progress providing high-quality tridimensional MR imaging of the cerebellum may explain its recent descriptions.
Authors: Ibrahim Erol Sandalcioglu; Thomas Gasser; Johannes Anthonius Petrus van de Nes; Udo Menken; Dietmar Stolke; Helmut Wiedemayer Journal: Childs Nerv Syst Date: 2004-12-23 Impact factor: 1.475
Authors: S B Hiremath; A Fitsiori; J Boto; C Torres; N Zakhari; J-L Dietemann; T R Meling; M I Vargas Journal: AJNR Am J Neuroradiol Date: 2020-09-17 Impact factor: 3.825
Authors: Gustavo Soto-Ares; Louise Devisme; Sylvie Jorriot; Berengere Deries; Jean P Pruvo; Marie M Ruchoux Journal: AJNR Am J Neuroradiol Date: 2002-08 Impact factor: 3.825
Authors: Kimberly A Aldinger; Stephen J Mosca; Martine Tétreault; Jennifer C Dempsey; Gisele E Ishak; Taila Hartley; Ian G Phelps; Ryan E Lamont; Diana R O'Day; Donald Basel; Karen W Gripp; Laura Baker; Mark J Stephan; Francois P Bernier; Kym M Boycott; Jacek Majewski; Jillian S Parboosingh; A Micheil Innes; Dan Doherty Journal: Am J Hum Genet Date: 2014-08-07 Impact factor: 11.025