Literature DB >> 1098677

[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].

V E Petzinger, J Homann, M Frimmer.   

Abstract

Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.

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Year:  1975        PMID： 1098677

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  12 in total

1.  Antagonistic effects against single lethal doses of Amanita phalloides.

Authors:  G L Floersheim
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

2.  Affinity labels for membrane components involved in the uptake of bile acids and of phallotoxins by hepatocytes. Development of covalently binding derivatives of bile acids and of compounds related to cholecystographic agents.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

3.  Transient desensibilization of isolated hepatocytes against phalloidin by treatment with phospholipase A.

Authors:  E Petzinger; U Rufeger; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978 Jan-Feb       Impact factor: 3.000

4.  A possible reason for the phalloidin tolerance of hepatoma cells.

Authors:  E Grundmann; E Petzinger; M Frimmer; C B Boschek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-12       Impact factor: 3.000

5.  Decreased sensitivity of isolated hepatocytes from baby rats, from regenerating and from poisoned livers to phalloidin.

Authors:  K Ziegler; E Petzinger; E Grundmann; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000

6.  Trypsin protection of hepatocytes against phalloidin.

Authors:  M Frimmer; E Petzinger; U Rufeger; L B Veil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-11       Impact factor: 3.000

7.  Temperature dependence of phalloidin response in isolated rat hepatocytes.

Authors:  M Frimmer; U Rufeger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-11       Impact factor: 3.000

8.  The role of bile acids in phalloidin poisoning.

Authors:  M Frimmer; E Petzinger; U Rufeger; L B Veil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

9.  [Isolated liver cells of the rat under the influence of a toxic factor from burnt human and animal skin (author's transl)].

Authors:  J Schölmerich; B Kremer; K Schmidt; H Setyadharma; I E Richter; G A Schoenenberger
Journal:  Langenbecks Arch Chir       Date:  1980

10.  Is ligandin relevant for the uptake and storage of phallotoxins in liver cells?

Authors:  K Ziegler; E Grundmann; L B Veil; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981       Impact factor: 3.000
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