Literature DB >> 600327

The role of bile acids in phalloidin poisoning.

M Frimmer, E Petzinger, U Rufeger, L B Veil.   

Abstract

Glycocholate and other bile acids inhibit the response of isolated hepatocytes to phalloidin in a concentration dependent manner. It is suggested that the inhibition is due to a block of phalloidin uptake. This interaction might explain the high specificity of phalloidin for liver tissue.

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Year:  1977        PMID： 600327     DOI： 10.1007/bf00501430

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  17 in total

1.  CHANGES IN LIVER METABOLISM INDUCED BY THE POISONS OF AMANITA PHALLOIDES.

Authors:  O WIELAND
Journal:  Clin Chem       Date:  1965-02       Impact factor: 8.327

2.  Uptake of taurocholic acid into isolated rat-liver cells.

Authors:  L R Schwarz; R Burr; M Schwenk; E Pfaff; H Greim
Journal:  Eur J Biochem       Date:  1975-07-15

3.  Antagonistic effects against single lethal doses of Amanita phalloides.

Authors:  G L Floersheim
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

4.  Binding of a phallotoxin to protein filaments of plasma membrane of liver cell.

Authors:  V M Govindan; G Rohr; T Wieland; B Agostini
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973-09

5.  The influence of sodium dehydrocholate on the uptake of 3 H-desmethylphalloin by the perfused rat liver.

Authors:  F Lutz; S Herrmann; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

6.  [Studies on antamanide. XIV. Mode of action].

Authors:  T Wieland; H Faulstich; W Jahn; M V Govindan; H Puchinger; Z Kopitar; H Schmaus; A Schmitz
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1972-08

7.  [Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].

Authors:  V E Petzinger; J Homann; M Frimmer
Journal:  Arzneimittelforschung       Date:  1975-04

8.  [Phalloidin antagonists/3rd communication: effects of antamanide derivatives in isolated perfused rat livers (author's transl)].

Authors:  M Frimmer; E Petzinger
Journal:  Arzneimittelforschung       Date:  1975-09

9.  [Phalloidine antagonists. 1. Effects of silybine derivatives on isolated perfused rat liver].

Authors:  V M Frimmer; R Kroker
Journal:  Arzneimittelforschung       Date:  1975-03

10.  Phalloidin-induced proliferation of actin filaments within rat hepatocytes. Visualisation by electron microscopy and immunofluorescence.

Authors:  B Agostini; V M Govindan; W Hofmann; T Wieland
Journal:  Z Naturforsch C Biosci       Date:  1975 Nov-Dec
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  19 in total

1.  The lack of active bile acid transport in AS-30 D ascites hepatoma cells.

Authors:  R Kroker; M S Anwer; D Hegner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

2.  Protection of rats against phalloidin by ligation of bile duct.

Authors:  B Agostini; A K Walli; H Wieland
Journal:  Naturwissenschaften       Date:  1978-12

3.  Affinity labels for membrane components involved in the uptake of bile acids and of phallotoxins by hepatocytes. Development of covalently binding derivatives of bile acids and of compounds related to cholecystographic agents.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

4.  A possible reason for the phalloidin tolerance of hepatoma cells.

Authors:  E Grundmann; E Petzinger; M Frimmer; C B Boschek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-12       Impact factor: 3.000

5.  Decreased sensitivity of isolated hepatocytes from baby rats, from regenerating and from poisoned livers to phalloidin.

Authors:  K Ziegler; E Petzinger; E Grundmann; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000

6.  Phalloidin uptake by the liver of cholestatic rats in vivo, in isolated perfused liver and isolated hepatocytes.

Authors:  A K Walli; E Wieland; T Wieland
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-06       Impact factor: 3.000

7.  Energy linked uptake of demethylphalloin by isolated rat liver cells.

Authors:  E Petzinger; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-04       Impact factor: 3.000

8.  Competitive inhibition of the uptake of demethylphalloin by cholic acid in isolated hepatocytes. Evidence for a transport competition rather than a binding competition.

Authors:  E Petzinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000

9.  Chemical modification of membrane proteins by brominated taurodehydrocholate in isolated hepatocytes; relationship to the uptake of cholate and of phalloidin and to the sensitivity of hepatocytes to phalloidin.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

10.  Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga microcystis aeruginosa.

Authors:  M T Runnegar; I R Falconer; J Silver
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-11       Impact factor: 3.000
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