Literature DB >> 10953020

Insights into insulin resistance and type 2 diabetes from knockout mouse models.

T Kadowaki1.   

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Year:  2000        PMID: 10953020      PMCID: PMC380257          DOI: 10.1172/JCI10830

Source DB:  PubMed          Journal:  J Clin Invest        ISSN: 0021-9738            Impact factor:   14.808


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  49 in total

1.  Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.

Authors:  L Rossetti; A E Stenbit; W Chen; M Hu; N Barzilai; E B Katz; M J Charron
Journal:  J Clin Invest       Date:  1997-10-01       Impact factor: 14.808

2.  Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.

Authors:  N J Cox; M Frigge; D L Nicolae; P Concannon; C L Hanis; G I Bell; A Kong
Journal:  Nat Genet       Date:  1999-02       Impact factor: 38.330

3.  Disruption of IRS-2 causes type 2 diabetes in mice.

Authors:  D J Withers; J S Gutierrez; H Towery; D J Burks; J M Ren; S Previs; Y Zhang; D Bernal; S Pons; G I Shulman; S Bonner-Weir; M F White
Journal:  Nature       Date:  1998-02-26       Impact factor: 49.962

4.  Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

Authors:  H Abe; N Yamada; K Kamata; T Kuwaki; M Shimada; J Osuga; F Shionoiri; N Yahagi; T Kadowaki; H Tamemoto; S Ishibashi; Y Yazaki; M Makuuchi
Journal:  J Clin Invest       Date:  1998-04-15       Impact factor: 14.808

5.  Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis.

Authors:  S Cinti; S Eberbach; M Castellucci; D Accili
Journal:  Diabetologia       Date:  1998-02       Impact factor: 10.122

6.  Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

Authors:  A Okuno; H Tamemoto; K Tobe; K Ueki; Y Mori; K Iwamoto; K Umesono; Y Akanuma; T Fujiwara; H Horikoshi; Y Yazaki; T Kadowaki
Journal:  J Clin Invest       Date:  1998-03-15       Impact factor: 14.808

7.  GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

Authors:  A E Stenbit; T S Tsao; J Li; R Burcelin; D L Geenen; S M Factor; K Houseknecht; E B Katz; M J Charron
Journal:  Nat Med       Date:  1997-10       Impact factor: 53.440

8.  The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

Authors:  B E Lavan; W S Lane; G E Lienhard
Journal:  J Biol Chem       Date:  1997-04-25       Impact factor: 5.157

9.  A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Authors:  J C Brüning; M D Michael; J N Winnay; T Hayashi; D Hörsch; D Accili; L J Goodyear; C R Kahn
Journal:  Mol Cell       Date:  1998-11       Impact factor: 17.970

10.  A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

Authors:  S S Deeb; L Fajas; M Nemoto; J Pihlajamäki; L Mykkänen; J Kuusisto; M Laakso; W Fujimoto; J Auwerx
Journal:  Nat Genet       Date:  1998-11       Impact factor: 38.330

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  61 in total

1.  Unraveling the mechanism of action of thiazolidinediones.

Authors:  C R Kahn; L Chen; S E Cohen
Journal:  J Clin Invest       Date:  2000-12       Impact factor: 14.808

Review 2.  Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.

Authors:  J M Olefsky
Journal:  J Clin Invest       Date:  2000-08       Impact factor: 14.808

3.  PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors.

Authors:  Toru Akune; Shinsuke Ohba; Satoru Kamekura; Masayuki Yamaguchi; Ung-Il Chung; Naoto Kubota; Yasuo Terauchi; Yoshifumi Harada; Yoshiaki Azuma; Kozo Nakamura; Takashi Kadowaki; Hiroshi Kawaguchi
Journal:  J Clin Invest       Date:  2004-03       Impact factor: 14.808

Review 4.  New insights into the integrated physiology of insulin action.

Authors:  Yukari Kitamura; Domenico Accili
Journal:  Rev Endocr Metab Disord       Date:  2004-05       Impact factor: 6.514

Review 5.  Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells.

Authors:  Hiroshi Kawaguchi; Toru Akune; Masayuki Yamaguchi; Shinsuke Ohba; Naoshi Ogata; Ung-il Chung; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki; Kozo Nakamura
Journal:  J Bone Miner Metab       Date:  2005       Impact factor: 2.626

6.  A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice.

Authors:  Yoshihiro Shiomi; Toshimasa Yamauchi; Masato Iwabu; Miki Okada-Iwabu; Ryo Nakayama; Yuki Orikawa; Yoshichika Yoshioka; Koichiro Tanaka; Kohjiro Ueki; Takashi Kadowaki
Journal:  J Biol Chem       Date:  2015-04-23       Impact factor: 5.157

Review 7.  Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.

Authors:  Hideaki Kaneto; Naoto Katakami; Munehide Matsuhisa; Taka-aki Matsuoka
Journal:  Mediators Inflamm       Date:  2010-02-16       Impact factor: 4.711

8.  Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation.

Authors:  Corinne Lautier; Samira Ait El Mkadem; Eric Renard; Jean Frédéric Brun; Jean Christophe Gris; Jacques Bringer; Florin Grigorescu
Journal:  Hum Genet       Date:  2003-04-10       Impact factor: 4.132

9.  Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Authors:  Takeshi Imai; Reiko Takakuwa; Sandra Marchand; Emilie Dentz; Jean-Marc Bornert; Nadia Messaddeq; Olivia Wendling; Manuel Mark; Béatrice Desvergne; Walter Wahli; Pierre Chambon; Daniel Metzger
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-16       Impact factor: 11.205

10.  Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments.

Authors:  Karuna Rasineni; Ramesh Bellamkonda; Sreenivasa Reddy Singareddy; Saralakumari Desireddy
Journal:  J Physiol Biochem       Date:  2013-01-22       Impact factor: 4.158

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