Literature DB >> 15070754

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Takeshi Imai1, Reiko Takakuwa, Sandra Marchand, Emilie Dentz, Jean-Marc Bornert, Nadia Messaddeq, Olivia Wendling, Manuel Mark, Béatrice Desvergne, Walter Wahli, Pierre Chambon, Daniel Metzger.   

Abstract

The peroxisome proliferator-activated receptor gamma (PPARgamma) mediates the activity of the insulin-sensitizing thiazolidinediones and plays an important role in adipocyte differentiation and fat accretion. The analysis of PPARgamma functions in mature adipocytes is precluded by lethality of PPARgamma(-/-) fetuses and tetraploid-rescued pups. Therefore we have selectively ablated PPARgamma in adipocytes of adult mice by using the tamoxifen-dependent Cre-ER(T2) recombination system. We show that mature PPARgamma-null white and brown adipocytes die within a few days and are replaced by newly formed PPARgamma-positive adipocytes, demonstrating that PPARgamma is essential for the in vivo survival of mature adipocytes, in addition to its well established requirement for their differentiation. Our data suggest that potent PPARgamma antagonists could be used to acutely reduce obesity.

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Year:  2004        PMID： 15070754      PMCID： PMC384783          DOI： 10.1073/pnas.0400356101

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

Review 1.  Peroxisome proliferator-activated receptors: nuclear control of metabolism.

Authors:  B Desvergne; W Wahli
Journal:  Endocr Rev       Date:  1999-10       Impact factor: 19.871

Review 2.  Insights into insulin resistance and type 2 diabetes from knockout mouse models.

Authors:  T Kadowaki
Journal:  J Clin Invest       Date:  2000-08       Impact factor: 14.808

3.  SRC-1 and TIF2 control energy balance between white and brown adipose tissues.

Authors:  Frédéric Picard; Martine Géhin; Jean- Sébastien Annicotte; Stéphane Rocchi; Marie-France Champy; Bert W O'Malley; Pierre Chambon; Johan Auwerx
Journal:  Cell       Date:  2002-12-27       Impact factor: 41.582

4.  Site- and time-specific gene targeting in the mouse.

Authors:  D Metzger; P Chambon
Journal:  Methods       Date:  2001-05       Impact factor: 3.608

5.  A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity.

Authors:  Jennifer Rieusset; Fethi Touri; Liliane Michalik; Pascal Escher; Béatrice Desvergne; Eric Niesor; Walter Wahli
Journal:  Mol Endocrinol       Date:  2002-11

6.  PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.

Authors:  N Kubota; Y Terauchi; H Miki; H Tamemoto; T Yamauchi; K Komeda; S Satoh; R Nakano; C Ishii; T Sugiyama; K Eto; Y Tsubamoto; A Okuno; K Murakami; H Sekihara; G Hasegawa; M Naito; Y Toyoshima; S Tanaka; K Shiota; T Kitamura; T Fujita; O Ezaki; S Aizawa; T Kadowaki
Journal:  Mol Cell       Date:  1999-10       Impact factor: 17.970

7.  Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.

Authors:  T Yamauchi; H Waki; J Kamon; K Murakami; K Motojima; K Komeda; H Miki; N Kubota; Y Terauchi; A Tsuchida; N Tsuboyama-Kasaoka; N Yamauchi; T Ide; W Hori; S Kato; M Fukayama; Y Akanuma; O Ezaki; A Itai; R Nagai; S Kimura; K Tobe; H Kagechika; K Shudo; T Kadowaki
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

Review 8.  Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors.

Authors:  Chih-Hao Lee; Peter Olson; Ronald M Evans
Journal:  Endocrinology       Date:  2003-06       Impact factor: 4.736

9.  RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

Authors:  M Li; H Chiba; X Warot; N Messaddeq; C Gérard; P Chambon; D Metzger
Journal:  Development       Date:  2001-03       Impact factor: 6.868

10.  Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.

Authors:  T Imai; M Jiang; P Chambon; D Metzger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205
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  150 in total

1.  Differentially expressed genes in PPARγ-deficient MSCs.

Authors:  Yun Su; Xiaona Shen; Jie Chen; Carlos M Isales; Jing Zhao; Xing-Ming Shi
Journal:  Mol Cell Endocrinol       Date:  2017-07-31       Impact factor: 4.102

2.  PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

Authors:  Haruya Ohno; Kosaku Shinoda; Bruce M Spiegelman; Shingo Kajimura
Journal:  Cell Metab       Date:  2012-03-07       Impact factor: 27.287

3.  The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes.

Authors:  Gail Kilroy; Heather Kirk-Ballard; Lauren E Carter; Z Elizabeth Floyd
Journal:  Endocrinology       Date:  2012-01-31       Impact factor: 4.736

Review 4.  Autophagic degradation of mitochondria in white adipose tissue differentiation.

Authors:  Scott J Goldman; Yong Zhang; Shengkan Jin
Journal:  Antioxid Redox Signal       Date:  2011-03-16       Impact factor: 8.401

Review 5.  Forming functional fat: a growing understanding of adipocyte differentiation.

Authors:  Ana G Cristancho; Mitchell A Lazar
Journal:  Nat Rev Mol Cell Biol       Date:  2011-09-28       Impact factor: 94.444

6.  Hsp90 chaperones PPARγ and regulates differentiation and survival of 3T3-L1 adipocytes.

Authors:  M T Nguyen; P Csermely; C Sőti
Journal:  Cell Death Differ       Date:  2013-10-04       Impact factor: 15.828

Review 7.  PPARgamma in human and mouse physiology.

Authors:  Sami Heikkinen; Johan Auwerx; Carmen A Argmann
Journal:  Biochim Biophys Acta       Date:  2007-03-27

8.  SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.

Authors:  Amine Toubal; Karine Clément; Rongrong Fan; Patricia Ancel; Veronique Pelloux; Christine Rouault; Nicolas Veyrie; Agnes Hartemann; Eckardt Treuter; Nicolas Venteclef
Journal:  J Clin Invest       Date:  2012-12-10       Impact factor: 14.808

9.  Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis.

Authors:  Ken Kataoka; Dae Joon Kim; Steve Carbajal; John L Clifford; John DiGiovanni
Journal:  Carcinogenesis       Date:  2008-05-02       Impact factor: 4.944

10.  LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.

Authors:  Jérome Terrand; Véronique Bruban; Li Zhou; Wanfeng Gong; Zeina El Asmar; Petra May; Kai Zurhove; Philipp Haffner; Claude Philippe; Estelle Woldt; Rachel L Matz; Céline Gracia; Daniel Metzger; Johan Auwerx; Joachim Herz; Philippe Boucher
Journal:  J Biol Chem       Date:  2008-11-06       Impact factor: 5.157
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