| Literature DB >> 10952610 |
M Perilli1, B Segatore, M R de Massis, M L Riccio, C Bianchi, A Zollo, G M Rossolini, G Amicosante.
Abstract
A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of bla(TEM-72) in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.Entities:
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Year: 2000 PMID: 10952610 PMCID: PMC90100 DOI: 10.1128/AAC.44.9.2537-2539.2000
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191