Literature DB >> 11257046

New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.

C de Champs1, C Monne, R Bonnet, W Sougakoff, D Sirot, C Chanal, J Sirot.   

Abstract

The sequences of the bla(TEM) genes encoding TEM-92 in Proteus mirabilis and Providencia stuartii isolates were determined and were found to be identical. Except for positions 218 (Lys-6) and 512 (Lys-104), the nucleotide sequence of bla(TEM-92) was identical to that of bla(TEM-20), including the sequence of the promoter region harboring a 135-bp deletion combined with a G-162-->T substitution. The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6-->Lys) in the peptide signal.

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Year:  2001        PMID： 11257046      PMCID： PMC90455          DOI： 10.1128/AAC.45.4.1278-1280.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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