| Literature DB >> 10937727 |
B Musicki1, A M Periers, P Laurin, D Ferroud, Y Benedetti, S Lachaud, F Chatreaux, J L Haesslein, A Iltis, C Pierre, J Khider, N Tessot, M Airault, J Demassey, C Dupuis-Hamelin, P Lassaigne, A Bonnefoy, P Vicat, M Klich.
Abstract
A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5'5'-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity.Entities:
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Year: 2000 PMID： 10937727 DOI： 10.1016/s0960-894x(00)00304-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823