| Literature DB >> 10932211 |
Abstract
Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.Entities:
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Year: 2000 PMID： 10932211 DOI： 10.1038/78595
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440