Literature DB >> 1091237

Molecular pathogenesis of systemic lupus erythematosus.

Z S Alekberova, M I Parfanovich, V A Nasonova, V M Zhdanov.   

Abstract

The study of patients with systemic lupus erythematosus revealed the close association of the disease with measles--or a related virus. High titres of antibodies to measles virus were found in patients that correlated with the course of the disease. Immunofluorescence tests revealed measles virus or a related antigen in lupus-affected tissues. Inclusion bodies consisting of paramyxovirus-like ribonucleoprotein structures were regularly detected in both affected tissues and leukocytes. Molecular hybridization of measles virus RNA with DNA from the affected tissues showed that DNA transcripts of measles or a closely related virus are integrated in the cellular nuclear DNA. Possible pathogenetic mechanisms of the disease are discussed.

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Year:  1975        PMID： 1091237      PMCID： PMC7086617          DOI： 10.1007/bf01320551

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  28 in total

1.  [Derangement of complement proteins with viruses derived from pemphigus, from herpetic dermatitis, from lupus erythematosus and from acute rheumatic arthritis].

Authors:  A BERGAMASCO
Journal:  Arch Ital Dermatol Sifilogr Venereol       Date:  1949

2.  Intraendothelial inclusions in kidneys of patients with systemic lupus erythematosus.

Authors:  C C Tisher; H B Kelso; R R Robinson; J C Gunnells; P M Burkholder
Journal:  Ann Intern Med       Date:  1971-10       Impact factor: 25.391

3.  Integration of measles virus nucleic acid into the cell genome.

Authors:  V M Zhdanov; M I Parfanovich
Journal:  Arch Gesamte Virusforsch       Date:  1974

4.  Antibodies to D.N.A. and viruses.

Authors:  T E Feltkamp; J J van Loghem; C J Lucas; J van der Noordaa; D J de Rooy; J H ten Veen
Journal:  Lancet       Date:  1971-06-05       Impact factor: 79.321

5.  Diagnostic import of virus-like particles in the glomerular endothelium of patients with systemic lupus erythematosus.

Authors:  H Grausz; L E Earley; B G Stephens; J C Lee; J Hopper
Journal:  N Engl J Med       Date:  1970-09-03       Impact factor: 91.245

6.  [Clinical peculiarities of the course of systemic lupus erythrematosus].

Authors:  V A Nasonova
Journal:  Vopr Revm       Date:  1967 Apr-Jun

7.  [Clinical aspects and diagnosis of systemic lupus erythematosus].

Authors:  V A Nasonova
Journal:  Klin Med (Mosk)       Date:  1967-10

8.  Cytoplasmic tubular structures in kidney biopsies in systemic lupus erythematosus.

Authors:  E R Hurd; E Eigenbrodt; M Ziff; S W Strunk
Journal:  Arthritis Rheum       Date:  1969-10

9.  Antibodies to polynucleotides: distribution in human serums.

Authors:  D Koffler; R I Carr; V Agnello; T Fiezi; H G Kunkel
Journal:  Science       Date:  1969-12-26       Impact factor: 47.728

10.  Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.

Authors:  A H COONS; M H KAPLAN
Journal:  J Exp Med       Date:  1950-01-01       Impact factor: 14.307
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  7 in total

Review 1.  Integration of genomes on infectious viruses.

Authors:  V M Zhdanov
Journal:  Mol Cell Biochem       Date:  1977-03-21       Impact factor: 3.396

2.  Tubuloreticular structures in chicken bursa Fabricii lymphocytes.

Authors:  A P Alves de Matos; R Camara e Sousa
Journal:  Experientia       Date:  1978-09-15

Review 3.  Measles virus and its associated diseases.

Authors:  E M Morgan; F Rapp
Journal:  Bacteriol Rev       Date:  1977-09

4.  Autoimmunity induced in rabbits by rinderpest virus.

Authors:  A Fukuda; K Yamanouchi
Journal:  Infect Immun       Date:  1976-05       Impact factor: 3.441

Review 5.  The measles virus.

Authors:  V M Zhdanov
Journal:  Mol Cell Biochem       Date:  1980-01-16       Impact factor: 3.396

6.  Togavirus-like particles in renal epithelium of patients with systemic lupus erythematosus.

Authors:  Y Fonck-Cussac; J L Aublet-Cuvelier; J Fonck; M E Stoeckel; Y Lombard; A Porte
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1978-10-26

7.  Type C oncornavirus isolation studies in systemic lupus erythematosus. II. Attempted detection by viral RNA-dependent DNA polymerase assay.

Authors:  P E Phillips; R Hargrave-Granda
Journal:  Ann Rheum Dis       Date:  1978-06       Impact factor: 19.103
  7 in total

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