Literature DB >> 109085

Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.

E N Lalani, B Burchell.   

Abstract

Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.

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Year:  1979        PMID： 109085      PMCID： PMC1186469          DOI： 10.1042/bj1770993

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Reactivation of a pure defective UDP-glucuronyltransferase from homozygous Gunn rat liver.

Authors:  P J Weatherill; B Burchell
Journal:  FEBS Lett       Date:  1978-03-15       Impact factor: 4.124

4.  Inhibition of hexobarbital metabolism by diethylnitrosamine.

Authors:  I H Stevenson; D T Greenwood
Journal:  Biochem Pharmacol       Date:  1968-05       Impact factor: 5.858

5.  Animal model of human disease. Crigler-Najjar Syndrome. Animal model: hereditary nonhemolytic unconjugated hyperbilirubinemia in Gunn rats.

Authors:  C E Cornelius; I M Arias
Journal:  Am J Pathol       Date:  1972-11       Impact factor: 4.307

6.  Regulation of microsomal enzymes by phospholipids. VI. Abnormal enzyme-lipid interactions in liver microsomes from Gunn rats.

Authors:  D Zakim; J Goldenberg; D A Vessey
Journal:  Biochim Biophys Acta       Date:  1973-02-28

7.  Studies on the activation in vitro of glucuronyltransferase.

Authors:  A Winsnes
Journal:  Biochim Biophys Acta       Date:  1969-11-04

8.  Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats--in vitro activation by diethylnitrosamine.

Authors:  I Stevenson; D Greenwood; J McEwen
Journal:  Biochem Biophys Res Commun       Date:  1968-09-06       Impact factor: 3.575

9.  Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver.

Authors:  B Burchell
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857

10.  Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver.

Authors:  K P Heirwegh; M Van de Vijver; J Fevery
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857
  10 in total
  3 in total

1.  Immunochemical comparison of UDP-glucuronyltransferase from Gunn- and Wistar-rat livers.

Authors:  P J Weatherill; S M Kennedy; B Burchell
Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

2.  Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats.

Authors:  L Braun; M J Coffey; F Puskás; T Kardon; G Nagy; A A Conley; B Burchell; J Mandl
Journal:  Biochem J       Date:  1998-12-15       Impact factor: 3.857

3.  Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.

Authors:  M Matsui; H K Watanabe
Journal:  Biochem J       Date:  1982-01-15       Impact factor: 3.857
  3 in total

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