Literature DB >> 10894172

Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: a possible mechanism for its neuroprotective activity.

R Huang1, Y Chen, A C Yu, L Hertz.   

Abstract

Dexmedetomidine is a highly specific alpha2-adrenergic agonist, which is used clinically as an anesthetic adjuvant and in animal experiments has a neuroprotective effect during ischemia. The current study showed that dexmedetomidine enhances glutamine disposal by oxidative metabolism in astrocytes. This effect occurs at pharmacologically relevant concentrations. It is exerted on alpha2-adrenergic receptors and not on imidazoline-preferring sites, and it is large enough to reduce the availability of glutamine as a precursor of neurotoxic glutamate.

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Year:  2000        PMID： 10894172     DOI： 10.1097/00004647-200006000-00001

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  9 in total

1.  Neuroprotection by alpha 2-adrenergic agonists in cerebral ischemia.

Authors:  Yonghua Zhang; Harold K Kimelberg
Journal:  Curr Neuropharmacol       Date:  2005-10       Impact factor: 7.363

2.  Use of α(2)-Agonists in Neuroanesthesia: An Overview.

Authors:  Ehab Farag; Maged Argalious; Daniel I Sessler; Andrea Kurz; Zeyd Y Ebrahim; Armin Schubert
Journal:  Ochsner J       Date:  2011

3.  Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats.

Authors:  Xiaoyan Ren; Hong Ma; Zhiyi Zuo
Journal:  J Neuroimmune Pharmacol       Date:  2016-03-02       Impact factor: 4.147

Review 4.  Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.

Authors:  Leif Hertz; Douglas L Rothman; Baoman Li; Liang Peng
Journal:  Front Behav Neurosci       Date:  2015-02-20       Impact factor: 3.558

5.  Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats.

Authors:  Xianzhang Zeng; Honglei Wang; Xichun Xing; Qi Wang; Wenzhi Li
Journal:  PLoS One       Date:  2016-03-16       Impact factor: 3.240

6.  Dexmedetomidine as an Anesthetic Adjuvant in Cardiac Surgery: a Cohort Study.

Authors:  Paulo Gabriel Melo Brandão; Francisco Ricardo Lobo; Serginando Laudenir Ramin; Yasser Sakr; Mauricio Nassau Machado; Suzana Margareth Lobo
Journal:  Braz J Cardiovasc Surg       Date:  2016 May-Jun

Review 7.  Delirium in the Intensive Care Unit.

Authors:  Suresh Arumugam; Ayman El-Menyar; Ammar Al-Hassani; Gustav Strandvik; Mohammad Asim; Ahammed Mekkodithal; Insolvisagan Mudali; Hassan Al-Thani
Journal:  J Emerg Trauma Shock       Date:  2017 Jan-Mar

8.  Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-κB axis.

Authors:  Liangyuan Suo; Mingyu Wang
Journal:  BMC Anesthesiol       Date:  2022-04-29       Impact factor: 2.376

Review 9.  Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit.

Authors:  S Nelson; A J Muzyk; M H Bucklin; S Brudney; J P Gagliardi
Journal:  Biomed Res Int       Date:  2015-10-19       Impact factor: 3.411
  9 in total

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